Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution

Hiroshi Nagata, Yasutada Akiba, Hidekazu Suzuki, Hideyuki Okano, Toshifumi Hibi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalFEBS Letters
Volume580
Issue number1
DOIs
Publication statusPublished - 2006 Jan 9

Keywords

  • Differentiation
  • Mucosal restitution
  • Musashi-1
  • Stem cell

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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