Expression of Notch1 and Numb in small cell lung cancer

Hajime Kikuchi, Jun Sakakibara-Konishi, Megumi Furuta, Hiroshi Yokouchi, Hiroshi Nishihara, Shigeo Yamazaki, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Toshiyuki Harada, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Satoshi OizumiHiroyuki Suzuki, Takashi Ishida, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Mitsuru Munakata, Masaharu Nishimura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.

Original languageEnglish
Pages (from-to)10348-10358
Number of pages11
JournalOncotarget
Volume8
Issue number6
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Fingerprint

Small Cell Lung Carcinoma
Neoplasms
Oncogenes
Lung Neoplasms
Histology
Carcinogenesis
Thorax
Regression Analysis
Cell Line

Keywords

  • Immunohistochemistry
  • Notch1
  • Numb
  • Small cell lung cancer
  • Surgery

ASJC Scopus subject areas

  • Oncology

Cite this

Kikuchi, H., Sakakibara-Konishi, J., Furuta, M., Yokouchi, H., Nishihara, H., Yamazaki, S., ... Nishimura, M. (2017). Expression of Notch1 and Numb in small cell lung cancer. Oncotarget, 8(6), 10348-10358. https://doi.org/10.18632/oncotarget.14411

Expression of Notch1 and Numb in small cell lung cancer. / Kikuchi, Hajime; Sakakibara-Konishi, Jun; Furuta, Megumi; Yokouchi, Hiroshi; Nishihara, Hiroshi; Yamazaki, Shigeo; Uramoto, Hidetaka; Tanaka, Fumihiro; Harada, Masao; Akie, Kenji; Sugaya, Fumiko; Fujita, Yuka; Takamura, Kei; Kojima, Tetsuya; Harada, Toshiyuki; Higuchi, Mitsunori; Honjo, Osamu; Minami, Yoshinori; Watanabe, Naomi; Oizumi, Satoshi; Suzuki, Hiroyuki; Ishida, Takashi; Dosaka-Akita, Hirotoshi; Isobe, Hiroshi; Munakata, Mitsuru; Nishimura, Masaharu.

In: Oncotarget, Vol. 8, No. 6, 01.01.2017, p. 10348-10358.

Research output: Contribution to journalArticle

Kikuchi, H, Sakakibara-Konishi, J, Furuta, M, Yokouchi, H, Nishihara, H, Yamazaki, S, Uramoto, H, Tanaka, F, Harada, M, Akie, K, Sugaya, F, Fujita, Y, Takamura, K, Kojima, T, Harada, T, Higuchi, M, Honjo, O, Minami, Y, Watanabe, N, Oizumi, S, Suzuki, H, Ishida, T, Dosaka-Akita, H, Isobe, H, Munakata, M & Nishimura, M 2017, 'Expression of Notch1 and Numb in small cell lung cancer', Oncotarget, vol. 8, no. 6, pp. 10348-10358. https://doi.org/10.18632/oncotarget.14411
Kikuchi H, Sakakibara-Konishi J, Furuta M, Yokouchi H, Nishihara H, Yamazaki S et al. Expression of Notch1 and Numb in small cell lung cancer. Oncotarget. 2017 Jan 1;8(6):10348-10358. https://doi.org/10.18632/oncotarget.14411
Kikuchi, Hajime ; Sakakibara-Konishi, Jun ; Furuta, Megumi ; Yokouchi, Hiroshi ; Nishihara, Hiroshi ; Yamazaki, Shigeo ; Uramoto, Hidetaka ; Tanaka, Fumihiro ; Harada, Masao ; Akie, Kenji ; Sugaya, Fumiko ; Fujita, Yuka ; Takamura, Kei ; Kojima, Tetsuya ; Harada, Toshiyuki ; Higuchi, Mitsunori ; Honjo, Osamu ; Minami, Yoshinori ; Watanabe, Naomi ; Oizumi, Satoshi ; Suzuki, Hiroyuki ; Ishida, Takashi ; Dosaka-Akita, Hirotoshi ; Isobe, Hiroshi ; Munakata, Mitsuru ; Nishimura, Masaharu. / Expression of Notch1 and Numb in small cell lung cancer. In: Oncotarget. 2017 ; Vol. 8, No. 6. pp. 10348-10358.
@article{1699aa06ffe04acea9a83b98a65c1421,
title = "Expression of Notch1 and Numb in small cell lung cancer",
abstract = "Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.",
keywords = "Immunohistochemistry, Notch1, Numb, Small cell lung cancer, Surgery",
author = "Hajime Kikuchi and Jun Sakakibara-Konishi and Megumi Furuta and Hiroshi Yokouchi and Hiroshi Nishihara and Shigeo Yamazaki and Hidetaka Uramoto and Fumihiro Tanaka and Masao Harada and Kenji Akie and Fumiko Sugaya and Yuka Fujita and Kei Takamura and Tetsuya Kojima and Toshiyuki Harada and Mitsunori Higuchi and Osamu Honjo and Yoshinori Minami and Naomi Watanabe and Satoshi Oizumi and Hiroyuki Suzuki and Takashi Ishida and Hirotoshi Dosaka-Akita and Hiroshi Isobe and Mitsuru Munakata and Masaharu Nishimura",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.14411",
language = "English",
volume = "8",
pages = "10348--10358",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "6",

}

TY - JOUR

T1 - Expression of Notch1 and Numb in small cell lung cancer

AU - Kikuchi, Hajime

AU - Sakakibara-Konishi, Jun

AU - Furuta, Megumi

AU - Yokouchi, Hiroshi

AU - Nishihara, Hiroshi

AU - Yamazaki, Shigeo

AU - Uramoto, Hidetaka

AU - Tanaka, Fumihiro

AU - Harada, Masao

AU - Akie, Kenji

AU - Sugaya, Fumiko

AU - Fujita, Yuka

AU - Takamura, Kei

AU - Kojima, Tetsuya

AU - Harada, Toshiyuki

AU - Higuchi, Mitsunori

AU - Honjo, Osamu

AU - Minami, Yoshinori

AU - Watanabe, Naomi

AU - Oizumi, Satoshi

AU - Suzuki, Hiroyuki

AU - Ishida, Takashi

AU - Dosaka-Akita, Hirotoshi

AU - Isobe, Hiroshi

AU - Munakata, Mitsuru

AU - Nishimura, Masaharu

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.

AB - Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.

KW - Immunohistochemistry

KW - Notch1

KW - Numb

KW - Small cell lung cancer

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=85012031522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012031522&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.14411

DO - 10.18632/oncotarget.14411

M3 - Article

AN - SCOPUS:85012031522

VL - 8

SP - 10348

EP - 10358

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 6

ER -