Expression of squamous cell carcinoma markers and adenocarcinoma markers in primary pulmonary neuroendocrine carcinomas

Kyohei Masai, Koji Tsuta, Mitsumasa Kawago, Takahiro Tatsumori, Tomoaki Kinno, Tomoko Taniyama, Akihiko Yoshida, Hisao Asamura, Hitoshi Tsuda

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Recent clinical trials have revealed that accurate histologic typing of non-small cell lung cancer is essential. Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. SOX2 (76.2%) had the greatest expression for NECs. CK5/6 (1.4%), desmocollin 3 (0.5%), and napsin A (0%) were expressed less or not at all in NECs. Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. In our study, CK5/6 and desmocollin 3 were highly specific markers for SQC, and napsin A was highly specific for ADC. These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume21
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1
Externally publishedYes

Keywords

  • immunohistochemical marker
  • lung
  • neuroendocrine tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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