Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells

Osamu Katoh, Yutaka Hattori, Takeyuki Sato, Akiro Kimura, Atsushi Kuramoto, Takashi Sugimura, Masaaki Terada

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20 Citations (Scopus)


K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. In CMK cells N- sam flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA). cDNA-polymerase chain reaction identified K- sam bek mRNA in human platelets, suggesting the involvement of HBGFs in megakaryocytopoiesis and functions of platelets.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 1992 Feb 28
Externally publishedYes


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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