Expression of the neural RNA-binding protein Musashi1 in pediatric brain tumors

Aya Nakano, Yonehiro Kanemura, Kanji Mori, Eri Kodama, Atsuyo Yamamoto, Hiroaki Sakamoto, Yasuhiro Nakamura, Hideyuki Okano, Mami Yamasaki, Norio Arita

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Musashi1 (MSI1) is an evolutionarily conserved RNA-binding protein, selectively expressed in neural stem cells (NSCs) and considered a versatile marker for normal NSCs and tumor cell diagnosis. Here, we examined MSI1 expression in primary pediatric brain tumors, medulloblastomas and ependymomas, by double immunostaining with lineage phenotypic markers (Lin). These tumors highly express MSI1 and are heterogeneous, containing both MSI1+/Lin- tumor cells in regions of relatively high cellularity and proliferative activity and MSI1+/Lin+ tumor cells in regions of lower cellularity. These findings suggest that MSI1 may be a useful marker for characterizing tumor heterogeneity and for examining in situ the analogy between normal NSCs and MSI1+ cells in pediatric brain tumors. This test could be easily applied to routine clinical diagnosis.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalPediatric Neurosurgery
Volume43
Issue number4
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Cancer stem cell
  • Ependymoma
  • Immunohistochemical analysis
  • Medulloblastoma
  • Musashi1
  • Neural stem cell

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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    Nakano, A., Kanemura, Y., Mori, K., Kodama, E., Yamamoto, A., Sakamoto, H., Nakamura, Y., Okano, H., Yamasaki, M., & Arita, N. (2007). Expression of the neural RNA-binding protein Musashi1 in pediatric brain tumors. Pediatric Neurosurgery, 43(4), 279-284. https://doi.org/10.1159/000103307