Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain

Yuko Gonda, Hitoshi Sakurai, Yukio Hirata, Hidenori Tabata, Itsuki Ajioka, Kazunori Nakajima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin-like growth factor binding protein-like 1 (IGFBPL-1) has a domain structure that resembles one in the insulin-like growth factor binding proteins (IGFBPs), which is a domain known to be bound by insulin-like growth factors (IGFs) with high affinity and to thereby affect cell growth and metabolism. However, the distribution and functions of IGFBPL-1 in the brain are not known. Thus, to clarify IGFBPL-1 expression profiles during development, we have investigated the expression patterns of IGFBPL-1 mRNA in developing mouse brains using in situ hybridization, focusing especially on the forebrain. On embryonic day (E)12, IGFBPL-1mRNA expressions were localized in the preplate of the neopallium, dorsal thalamus, the differentiating field of the epithalamus, and the hippocampus. On E14, strong expression was recognized in the subventricular zone (SVZ) and intermediate zone (IMZ) in the neopallium, hippocampus, the differentiating field of the epithalamus, and the dorsal thalamus. E14 expressions were generally the strongest among all the stages examined and signals decreased thereafter. At E16 and E18, IGFBPL-1mRNA was strongly detected in the hippocampus and the SVZ of the neopallium. In postnatal stages, mRNA was found only in the granule cell layer of the dentate gyrus (DG). Notably, at P20, expression was restricted to the deep fraction of the granule cell layer, the location of late-born DG neurons.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalGene Expression Patterns
Volume7
Issue number4
DOIs
Publication statusPublished - 2007 Feb

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Prosencephalon
Epithalamus
Neocortex
Hippocampus
Lateral Ventricles
Dentate Gyrus
Thalamus
Insulin-Like Growth Factor Binding Proteins
Messenger RNA
Brain
Somatomedins
In Situ Hybridization
Neurons
Growth

Keywords

  • Development
  • Forebrain
  • Hippocampus
  • In situ hybridization
  • Insulin-like growth factor binding protein-like 1
  • Mouse

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain. / Gonda, Yuko; Sakurai, Hitoshi; Hirata, Yukio; Tabata, Hidenori; Ajioka, Itsuki; Nakajima, Kazunori.

In: Gene Expression Patterns, Vol. 7, No. 4, 02.2007, p. 431-440.

Research output: Contribution to journalArticle

Gonda, Yuko ; Sakurai, Hitoshi ; Hirata, Yukio ; Tabata, Hidenori ; Ajioka, Itsuki ; Nakajima, Kazunori. / Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain. In: Gene Expression Patterns. 2007 ; Vol. 7, No. 4. pp. 431-440.
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