Extensive endobronchial growth of metastatic hepatocellular carcinoma resulting in respiratory failure

A case report

Rie Uchida, Yohei Masugi, Toshihiro Nishizawa, Tokuhiro Kimura, Taketo Yamada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intrabronchial involvement by metastatic tumors from extrapulmonary primary sites is referred to as "endobronchial metastasis", which is an uncommon mode of metastasis. Although various primary sites (for example, breast, colon, and kidney) have been reported previously, endobronchial metastasis of hepatocellular carcinoma (HCC) is rare. Here, we report a case of a 71-year-old woman with hepatitis C-related HCC, in whom respiratory failure due to bilateral endobronchial metastasis occurred. Notably, long tree-like tumor shadows reminiscent of the structure of the bronchial tree were observed in the bilateral lungs on computed tomography scan, and postmortem analysis clearly revealed metastatic HCC growing and spreading extensively in the lumina of the bronchi. This growth pattern is in sharp contrast to the ordinary endobronchial metastasis, which involves a relatively short segment of the unilateral bronchus. This is the first case report of bilateral and extensive spreading of endobronchial metastatic HCC, and this phenomenon should be considered as a cause of dyspnea in advanced HCC patients.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalPathology Research and Practice
Volume206
Issue number2
DOIs
Publication statusPublished - 2010 Feb 15

Fingerprint

Respiratory Insufficiency
Hepatocellular Carcinoma
Neoplasm Metastasis
Growth
Bronchi
Hepatitis C
Dyspnea
Neoplasms
Colon
Breast
Tomography
Kidney
Lung

Keywords

  • Autopsy
  • Endobronchial metastasis
  • Hepatocellular carcinoma
  • Pulmonary metastasis
  • Respiratory failure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Extensive endobronchial growth of metastatic hepatocellular carcinoma resulting in respiratory failure : A case report. / Uchida, Rie; Masugi, Yohei; Nishizawa, Toshihiro; Kimura, Tokuhiro; Yamada, Taketo.

In: Pathology Research and Practice, Vol. 206, No. 2, 15.02.2010, p. 116-120.

Research output: Contribution to journalArticle

Uchida, Rie ; Masugi, Yohei ; Nishizawa, Toshihiro ; Kimura, Tokuhiro ; Yamada, Taketo. / Extensive endobronchial growth of metastatic hepatocellular carcinoma resulting in respiratory failure : A case report. In: Pathology Research and Practice. 2010 ; Vol. 206, No. 2. pp. 116-120.
@article{cfc78fb6aab44b54a2b40352f04ab3aa,
title = "Extensive endobronchial growth of metastatic hepatocellular carcinoma resulting in respiratory failure: A case report",
abstract = "Intrabronchial involvement by metastatic tumors from extrapulmonary primary sites is referred to as {"}endobronchial metastasis{"}, which is an uncommon mode of metastasis. Although various primary sites (for example, breast, colon, and kidney) have been reported previously, endobronchial metastasis of hepatocellular carcinoma (HCC) is rare. Here, we report a case of a 71-year-old woman with hepatitis C-related HCC, in whom respiratory failure due to bilateral endobronchial metastasis occurred. Notably, long tree-like tumor shadows reminiscent of the structure of the bronchial tree were observed in the bilateral lungs on computed tomography scan, and postmortem analysis clearly revealed metastatic HCC growing and spreading extensively in the lumina of the bronchi. This growth pattern is in sharp contrast to the ordinary endobronchial metastasis, which involves a relatively short segment of the unilateral bronchus. This is the first case report of bilateral and extensive spreading of endobronchial metastatic HCC, and this phenomenon should be considered as a cause of dyspnea in advanced HCC patients.",
keywords = "Autopsy, Endobronchial metastasis, Hepatocellular carcinoma, Pulmonary metastasis, Respiratory failure",
author = "Rie Uchida and Yohei Masugi and Toshihiro Nishizawa and Tokuhiro Kimura and Taketo Yamada",
year = "2010",
month = "2",
day = "15",
doi = "10.1016/j.prp.2009.03.001",
language = "English",
volume = "206",
pages = "116--120",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "2",

}

TY - JOUR

T1 - Extensive endobronchial growth of metastatic hepatocellular carcinoma resulting in respiratory failure

T2 - A case report

AU - Uchida, Rie

AU - Masugi, Yohei

AU - Nishizawa, Toshihiro

AU - Kimura, Tokuhiro

AU - Yamada, Taketo

PY - 2010/2/15

Y1 - 2010/2/15

N2 - Intrabronchial involvement by metastatic tumors from extrapulmonary primary sites is referred to as "endobronchial metastasis", which is an uncommon mode of metastasis. Although various primary sites (for example, breast, colon, and kidney) have been reported previously, endobronchial metastasis of hepatocellular carcinoma (HCC) is rare. Here, we report a case of a 71-year-old woman with hepatitis C-related HCC, in whom respiratory failure due to bilateral endobronchial metastasis occurred. Notably, long tree-like tumor shadows reminiscent of the structure of the bronchial tree were observed in the bilateral lungs on computed tomography scan, and postmortem analysis clearly revealed metastatic HCC growing and spreading extensively in the lumina of the bronchi. This growth pattern is in sharp contrast to the ordinary endobronchial metastasis, which involves a relatively short segment of the unilateral bronchus. This is the first case report of bilateral and extensive spreading of endobronchial metastatic HCC, and this phenomenon should be considered as a cause of dyspnea in advanced HCC patients.

AB - Intrabronchial involvement by metastatic tumors from extrapulmonary primary sites is referred to as "endobronchial metastasis", which is an uncommon mode of metastasis. Although various primary sites (for example, breast, colon, and kidney) have been reported previously, endobronchial metastasis of hepatocellular carcinoma (HCC) is rare. Here, we report a case of a 71-year-old woman with hepatitis C-related HCC, in whom respiratory failure due to bilateral endobronchial metastasis occurred. Notably, long tree-like tumor shadows reminiscent of the structure of the bronchial tree were observed in the bilateral lungs on computed tomography scan, and postmortem analysis clearly revealed metastatic HCC growing and spreading extensively in the lumina of the bronchi. This growth pattern is in sharp contrast to the ordinary endobronchial metastasis, which involves a relatively short segment of the unilateral bronchus. This is the first case report of bilateral and extensive spreading of endobronchial metastatic HCC, and this phenomenon should be considered as a cause of dyspnea in advanced HCC patients.

KW - Autopsy

KW - Endobronchial metastasis

KW - Hepatocellular carcinoma

KW - Pulmonary metastasis

KW - Respiratory failure

UR - http://www.scopus.com/inward/record.url?scp=74449092735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74449092735&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2009.03.001

DO - 10.1016/j.prp.2009.03.001

M3 - Article

VL - 206

SP - 116

EP - 120

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

IS - 2

ER -