Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature

Yutaka Endo, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Shutaro Hori, Masanori Odaira, Takahiro Yokose, Kaori Kameyama, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Pheochromocytoma is a catecholamine-secreting tumour that leads to various symptoms. Haemoptysis is rarely caused by a pheochromocytoma occurring outside the bronchus or thoracic cavity. Here, we report the case of an extra-adrenal abdominal pheochromocytoma initially manifesting as haemoptysis/dyspnoea during exercise without classic symptoms. Case presentation: A 22-year-old man with a history of severe dyspnoea experienced difficulties in breathing following a marathon owing to haemoptysis that required ventilator management 1 year before presentation. His father had undergone surgery for ectopic pheochromocytoma. Computed tomography (CT) revealed a 30-mm tumour between the inferior vena cava and pancreatic head while urinalysis revealed abnormally high noradrenaline levels. He was clinically diagnosed with an extra-adrenal abdominal ectopic pheochromocytoma. After controlling blood pressure, surgery was performed, and the tumour was successfully removed. Histopathology revealed chromogranin A (+), synaptophysin (+), S100 protein (+), and MIB-1 index of 1%. Therefore, the patient was finally diagnosed with extra-adrenal abdominal ectopic pheochromocytoma. Conclusions: Haemoptysis is a rare manifestation of abdominal ectopic paraganglioma. Prompt consideration of pheochromocytoma/paraganglioma when patients experience haemoptysis without any other possible aetiology may prevent inappropriate diagnosis and treatment and ultimately fatalities.

Original languageEnglish
Article number13
JournalBMC surgery
Volume21
Issue number1
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • Extra-adrenal abdominal pheochromocytoma
  • Haemoptysis
  • Paraganglioma

ASJC Scopus subject areas

  • Surgery

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