Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma

Kosuke Yoshida, Akira Yokoi, Juntaro Matsuzaki, Tomoyasu Kato, Takahiro Ochiya, Hiroaki Kajiyama, Yusuke Yamamoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

High-grade serous ovarian carcinoma is a leading cause of death in female patients worldwide. MicroRNAs (miRNAs) are stable noncoding RNAs in the peripheral blood that reflect a patient’s condition, and therefore, they have received substantial attention as noninvasive biomarkers in various diseases. We previously reported the usefulness of serum miRNAs as diagnostic biomarkers. Here, we investigated the prognostic impact of the serum miRNA profile. We used the GSE106817 dataset, which included preoperative miRNA profiles of patients with ovarian malignancies. Excluding patients with other malignancy or insufficient prognostic information, we included 175 patients with high-grade serous ovarian carcinoma. All patients except four underwent surgery and received chemotherapy as initial treatment. The median follow-up period was 54.6 months (range, 3.5-144.1 months). Univariate Cox regression analysis revealed that higher levels of miR-187-5p and miR-6870-5p were associated with both poorer progression-free survival (PFS) and overall survival (OS), and miR-1908-5p, miR-6727-5p, and miR-6850-5p were poor prognostic indicators of PFS. The OS and PFS prognostic indices were then calculated using the expression values of three prognostic miRNAs. Multivariate Cox regression analysis showed that both indices were significantly independent poor prognostic factors (hazard ratio for OS and PFS, 2.343 [P =.015] and 2.357 [P =.005], respectively). In conclusion, circulating miRNA profiles can potentially provide information to predict the prognosis of patients with high-grade serous ovarian carcinoma. Therefore, there is a strong demand for early clinical application of circulating miRNAs as noninvasive biomarkers.

Original languageEnglish
Pages (from-to)4977-4986
Number of pages10
JournalCancer science
Volume112
Issue number12
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • circulating miRNA
  • high-grade serous ovarian carcinoma
  • miR-187-5p
  • miR-6870-5p
  • noninvasive biomarker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma'. Together they form a unique fingerprint.

Cite this