Extracellular microRNAs and oxidative stress in liver injury: A systematic mini review

Juntaro Matsuzaki, Takahiro Ochiya

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Recent evidence has suggested that extracelluar microRNAs crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury. Endothelial cell-specific miR-126-3p was the most studied extracellular miRNA associated with oxidative stress. In addition, we highlight some reports that describe the mechanisms of how oxidative stress affects extracellular microRNA profiles in liver injury. In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera. The release of miR-122-5p, miR-192-5p, and miR-1224-5p from hepatocytes may be attributed to oxidative stress. miR-223-3p could be released from neutrophils and suppress oxidative stress in the liver. Elucidation of the mechanisms of the interaction between extracellular microRNAs and oxidative stress would improve our pathophysiological understanding as well as future medical practice.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume63
Issue number1
DOIs
Publication statusPublished - 2018 Jul 1
Externally publishedYes

Fingerprint

Oxidative stress
MicroRNAs
Liver
Oxidative Stress
Wounds and Injuries
Endothelial cells
Neurology
Biomarkers
Hepatocytes
Neutrophils
Homeostasis
Cardiovascular Diseases
Central Nervous System
Endothelial Cells
Association reactions
Communication
Serum

Keywords

  • Extracellular vesicle
  • Liquid biopsy
  • Liver injury
  • MicroRNA

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Extracellular microRNAs and oxidative stress in liver injury : A systematic mini review. / Matsuzaki, Juntaro; Ochiya, Takahiro.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 63, No. 1, 01.07.2018, p. 6-11.

Research output: Contribution to journalReview article

@article{49542f45844440bcb15d4af87b113d65,
title = "Extracellular microRNAs and oxidative stress in liver injury: A systematic mini review",
abstract = "Recent evidence has suggested that extracelluar microRNAs crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury. Endothelial cell-specific miR-126-3p was the most studied extracellular miRNA associated with oxidative stress. In addition, we highlight some reports that describe the mechanisms of how oxidative stress affects extracellular microRNA profiles in liver injury. In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera. The release of miR-122-5p, miR-192-5p, and miR-1224-5p from hepatocytes may be attributed to oxidative stress. miR-223-3p could be released from neutrophils and suppress oxidative stress in the liver. Elucidation of the mechanisms of the interaction between extracellular microRNAs and oxidative stress would improve our pathophysiological understanding as well as future medical practice.",
keywords = "Extracellular vesicle, Liquid biopsy, Liver injury, MicroRNA",
author = "Juntaro Matsuzaki and Takahiro Ochiya",
year = "2018",
month = "7",
day = "1",
doi = "10.3164/jcbn.17-123",
language = "English",
volume = "63",
pages = "6--11",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "1",

}

TY - JOUR

T1 - Extracellular microRNAs and oxidative stress in liver injury

T2 - A systematic mini review

AU - Matsuzaki, Juntaro

AU - Ochiya, Takahiro

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Recent evidence has suggested that extracelluar microRNAs crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury. Endothelial cell-specific miR-126-3p was the most studied extracellular miRNA associated with oxidative stress. In addition, we highlight some reports that describe the mechanisms of how oxidative stress affects extracellular microRNA profiles in liver injury. In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera. The release of miR-122-5p, miR-192-5p, and miR-1224-5p from hepatocytes may be attributed to oxidative stress. miR-223-3p could be released from neutrophils and suppress oxidative stress in the liver. Elucidation of the mechanisms of the interaction between extracellular microRNAs and oxidative stress would improve our pathophysiological understanding as well as future medical practice.

AB - Recent evidence has suggested that extracelluar microRNAs crucial roles in intercellular communications and are promising as minimally invasive biomarkers for various diseases including cancers. Oxidative stress also plays an essential role in homeostasis and disease development. This systematic review aims to clarify the current evidence on the interaction between oxidative stress and extracellular microRNAs. We identified 32 studies that provided information regarding the association between oxidative stress and extracellular microRNAs: 9 focused on the central nervous system, 11 focused on cardiovascular diseases, and 4 focused on liver injury. Endothelial cell-specific miR-126-3p was the most studied extracellular miRNA associated with oxidative stress. In addition, we highlight some reports that describe the mechanisms of how oxidative stress affects extracellular microRNA profiles in liver injury. In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera. The release of miR-122-5p, miR-192-5p, and miR-1224-5p from hepatocytes may be attributed to oxidative stress. miR-223-3p could be released from neutrophils and suppress oxidative stress in the liver. Elucidation of the mechanisms of the interaction between extracellular microRNAs and oxidative stress would improve our pathophysiological understanding as well as future medical practice.

KW - Extracellular vesicle

KW - Liquid biopsy

KW - Liver injury

KW - MicroRNA

UR - http://www.scopus.com/inward/record.url?scp=85049615030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049615030&partnerID=8YFLogxK

U2 - 10.3164/jcbn.17-123

DO - 10.3164/jcbn.17-123

M3 - Review article

AN - SCOPUS:85049615030

VL - 63

SP - 6

EP - 11

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 1

ER -