Extracellular talaporfin sodium-induced photosensitization reaction with various albumin animal species on myocardial cells in vitro

Emiyu Ogawa, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

It is reported that the albumin has different structure among animal species. We have proposed a new methodology of cardiac ablation using talaporfin sodium-induced photosensitization reaction with short drug-light interval to realize immediate and permanent therapeutic effect by singlet oxygen production mainly in the interstitial space. The photosensitization reaction efficacy with different animal species should be investing to consider the optimal animal therapeutic model to evaluate the therapeutic effect of new cardiac ablation methodology. We studied the cell-killing efficacy of extracellular talaporfin sodium-induced photosensitization reaction using talaporfin sodium on myocardial cells in vitro with different albumin animal species: human, canine, bovine, and porcine serum albumin. We obtained that the albumin concentration tendency on the binding ratio and cell lethality was different among the animal species but there was no correlation between binding ratio and cell lethality. We found that the cell lethality dependence on albumin concentration showed 2 different groups, human-canine and bovine-porcine. We think that the canine might be useful as a therapeutic animal model since the cytotoxicity tendency on albumin concentration was similar with that of human albumin. These cell lethality tendency difference would be suggested to explain by the existence of the diazepam site that talaporfin sodium binds mainly.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XXVIII
PublisherSPIE
Volume10062
ISBN (Electronic)9781510605657
DOIs
Publication statusPublished - 2017
EventOptical Interactions with Tissue and Cells XXVIII - San Francisco, United States
Duration: 2017 Jan 302017 Jan 31

Other

OtherOptical Interactions with Tissue and Cells XXVIII
CountryUnited States
CitySan Francisco
Period17/1/3017/1/31

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Keywords

  • Albumin
  • myocardial cell
  • photosensitization reaction

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ogawa, E., & Arai, T. (2017). Extracellular talaporfin sodium-induced photosensitization reaction with various albumin animal species on myocardial cells in vitro. In Optical Interactions with Tissue and Cells XXVIII (Vol. 10062). [100620O] SPIE. https://doi.org/10.1117/12.2250721