TY - CHAP
T1 - Extracellular vesicle-associated MMPs
T2 - A modulator of the tissue microenvironment
AU - Shimoda, Masayuki
N1 - Funding Information:
M.S. was supported by JSPS KAKENHI Grant 16K08719, Research Grant of the Princess Takamatsu Cancer Research Fund and grants from the Takeda Science Foundation, the Public Trust Fund for Clinical Cancer Research and Cancer Research Institute of Kanazawa University.
Funding Information:
M.S. was supported by JSPS KAKENHI Grant 16K08719, Research Grant of the Princess Takamatsu Cancer Research Fund and grants from the Takeda Science Foundation, the Public Trust Fund for Clinical Cancer Research and Cancer Research Institute of Kanazawa University., The author declares that no conflict of interest exists.
Publisher Copyright:
© 2019 Elsevier Inc.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.
AB - Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.
KW - A disintegrin and metalloproteinase (ADAM)
KW - Exosome
KW - Extracellular matrix (ECM)
KW - Extracellular vesicle (EV)
KW - Matrix metalloproteinase (MMP)
UR - http://www.scopus.com/inward/record.url?scp=85057026612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057026612&partnerID=8YFLogxK
U2 - 10.1016/bs.acc.2018.10.006
DO - 10.1016/bs.acc.2018.10.006
M3 - Chapter
C2 - 30612606
AN - SCOPUS:85057026612
SN - 9780128171431
T3 - Advances in Clinical Chemistry
SP - 35
EP - 66
BT - Advances in Clinical Chemistry
A2 - Makowski, Gregory S.
PB - Academic Press Inc.
ER -
