Extracellular vesicle-associated MMPs: A modulator of the tissue microenvironment

Research output: Contribution to journalArticle

Abstract

Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.

Original languageEnglish
JournalAdvances in Clinical Chemistry
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Matrix Metalloproteinases
Modulators
Tissue
Extracellular Matrix Proteins
Body fluids
Metalloproteases
Nucleic Acids
Proteins
Lipids
Degradation
Body Fluids
Extracellular Vesicles
Communication

Keywords

  • A disintegrin and metalloproteinase (ADAM)
  • Exosome
  • Extracellular matrix (ECM)
  • Extracellular vesicle (EV)
  • Matrix metalloproteinase (MMP)

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

Cite this

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abstract = "Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.",
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