Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia

T. Hayashida, Y. Araki, K. Kawano, Tetsuji Kamata, Y. Kawai, K. Takeuchi, K. Watanabe, Shinichiro Okamoto, T. Ogawa

Research output: Contribution to journalArticle

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Abstract

We present a case of acute monocytic leukemia presenting with extramedullary disease clinically resembling lymphoma. A 36 year-old man presented with arthralgia and was found to have skin eruption, nasopharyngeal mass, hepatosplenomegaly and superficial lymphadenopathy. The biopsies of those lesions as well as bone marrow revealed infiltration of CD45 positive large atypical cells and were interpreted as malignant lymphoma. At that time blood film showed leuko-erythroblastic picture, but no atypical cells were noted. He was treated with CHOP followed by VEPA chemotherapy and achieved partial remission. Four months later headache and double vision occurred with the same atypical cell in the cerebrospinal fluid. The cells were identified as monoblasts by cytochemistry and immunophenotype. The diagnosis of aleukemic acute monocytic leukemia was made and its CNS involvement was successfully treated with chemotherapy with DHAP and intrathecal MTX. However, two months later, blasts finally appeared in the peripheral blood and the patient died of multiorgan failure eight months after presentation. The blasts were positive for T cell markers (CD2, 4, 8) and NK marker (NKH-1) as well as monocytic markers. This finding, together with those by other investigators, may indicate the association between these immunophenotypes and extramedullary manifestations of acute monocytic leukemia.

Original languageEnglish
Pages (from-to)1679-1684
Number of pages6
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology
Volume33
Issue number11
Publication statusPublished - 1992 Nov

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Leukemia, Monocytic, Acute
Lymphoma
Monocyte-Macrophage Precursor Cells
Drug Therapy
Histocytochemistry
Diplopia
Arthralgia
Headache
Cerebrospinal Fluid
Bone Marrow
Research Personnel
T-Lymphocytes
Biopsy
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hayashida, T., Araki, Y., Kawano, K., Kamata, T., Kawai, Y., Takeuchi, K., ... Ogawa, T. (1992). Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia. [Rinsho ketsueki] The Japanese journal of clinical hematology, 33(11), 1679-1684.

Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia. / Hayashida, T.; Araki, Y.; Kawano, K.; Kamata, Tetsuji; Kawai, Y.; Takeuchi, K.; Watanabe, K.; Okamoto, Shinichiro; Ogawa, T.

In: [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 33, No. 11, 11.1992, p. 1679-1684.

Research output: Contribution to journalArticle

Hayashida, T, Araki, Y, Kawano, K, Kamata, T, Kawai, Y, Takeuchi, K, Watanabe, K, Okamoto, S & Ogawa, T 1992, 'Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia', [Rinsho ketsueki] The Japanese journal of clinical hematology, vol. 33, no. 11, pp. 1679-1684.
Hayashida, T. ; Araki, Y. ; Kawano, K. ; Kamata, Tetsuji ; Kawai, Y. ; Takeuchi, K. ; Watanabe, K. ; Okamoto, Shinichiro ; Ogawa, T. / Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia. In: [Rinsho ketsueki] The Japanese journal of clinical hematology. 1992 ; Vol. 33, No. 11. pp. 1679-1684.
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