Extramedullary myeloid tumour (EMMT) of the gallbladder

Hidenori Ojima, T. Hasegawa, Y. Matsuno, Michiie Sakamoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 × 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.

Original languageEnglish
Pages (from-to)211-213
Number of pages3
JournalJournal of Clinical Pathology
Volume58
Issue number2
DOIs
Publication statusPublished - 2005 Feb

Fingerprint

Gallbladder
Leukemia
Proto-Oncogene Proteins c-kit
Neoplasms
Needle Biopsy
Jaundice
Combination Drug Therapy
Acute Myeloid Leukemia
Peroxidase
Cytoplasm
Adenocarcinoma
Tomography
Staining and Labeling
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Extramedullary myeloid tumour (EMMT) of the gallbladder. / Ojima, Hidenori; Hasegawa, T.; Matsuno, Y.; Sakamoto, Michiie.

In: Journal of Clinical Pathology, Vol. 58, No. 2, 02.2005, p. 211-213.

Research output: Contribution to journalArticle

@article{0f85cd81aa804b90a13bf5e004396ba9,
title = "Extramedullary myeloid tumour (EMMT) of the gallbladder",
abstract = "This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 × 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.",
author = "Hidenori Ojima and T. Hasegawa and Y. Matsuno and Michiie Sakamoto",
year = "2005",
month = "2",
doi = "10.1136/jcp.2004.019729",
language = "English",
volume = "58",
pages = "211--213",
journal = "Journal of Clinical Pathology - Clinical Molecular Pathology",
issn = "0021-9746",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Extramedullary myeloid tumour (EMMT) of the gallbladder

AU - Ojima, Hidenori

AU - Hasegawa, T.

AU - Matsuno, Y.

AU - Sakamoto, Michiie

PY - 2005/2

Y1 - 2005/2

N2 - This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 × 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.

AB - This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 × 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.

UR - http://www.scopus.com/inward/record.url?scp=13244276335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13244276335&partnerID=8YFLogxK

U2 - 10.1136/jcp.2004.019729

DO - 10.1136/jcp.2004.019729

M3 - Article

C2 - 15677545

AN - SCOPUS:13244276335

VL - 58

SP - 211

EP - 213

JO - Journal of Clinical Pathology - Clinical Molecular Pathology

JF - Journal of Clinical Pathology - Clinical Molecular Pathology

SN - 0021-9746

IS - 2

ER -