Abstract
It was found that microwave irradiation under strictly controlled temperature conditions drastically enhanced the catalytic atropo- enantioselective CoreyBakshiShibata (CBS) reduction of biaryl lactones. Since the high enantioselectivity was maintained completely compared with conventional heating conditions, the present enhancement is not caused by simple microwave heating. It was also revealed that the microwave irradiation could accelerate the racemization of the atropoenantiomers of optically active biaryl lactone. It could be concluded that the drastic enhancement with retention of the high enantioselectivity was caused not by simple heating, but by some direct microwave effect on the substrate molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | Chemistry Letters |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Extraordinary microwave effect on atropo-enantioselective catalytic reduction of biaryl lactones. / Nushiro, Kazuya; Kikuchi, Satoshi; Yamada, Tohru.
In: Chemistry Letters, Vol. 42, No. 2, 2013, p. 165-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Extraordinary microwave effect on atropo-enantioselective catalytic reduction of biaryl lactones
AU - Nushiro, Kazuya
AU - Kikuchi, Satoshi
AU - Yamada, Tohru
PY - 2013
Y1 - 2013
N2 - It was found that microwave irradiation under strictly controlled temperature conditions drastically enhanced the catalytic atropo- enantioselective CoreyBakshiShibata (CBS) reduction of biaryl lactones. Since the high enantioselectivity was maintained completely compared with conventional heating conditions, the present enhancement is not caused by simple microwave heating. It was also revealed that the microwave irradiation could accelerate the racemization of the atropoenantiomers of optically active biaryl lactone. It could be concluded that the drastic enhancement with retention of the high enantioselectivity was caused not by simple heating, but by some direct microwave effect on the substrate molecule.
AB - It was found that microwave irradiation under strictly controlled temperature conditions drastically enhanced the catalytic atropo- enantioselective CoreyBakshiShibata (CBS) reduction of biaryl lactones. Since the high enantioselectivity was maintained completely compared with conventional heating conditions, the present enhancement is not caused by simple microwave heating. It was also revealed that the microwave irradiation could accelerate the racemization of the atropoenantiomers of optically active biaryl lactone. It could be concluded that the drastic enhancement with retention of the high enantioselectivity was caused not by simple heating, but by some direct microwave effect on the substrate molecule.
UR - http://www.scopus.com/inward/record.url?scp=84873973186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873973186&partnerID=8YFLogxK
U2 - 10.1246/cl.2013.165
DO - 10.1246/cl.2013.165
M3 - Article
AN - SCOPUS:84873973186
VL - 42
SP - 165
EP - 167
JO - Chemistry Letters
JF - Chemistry Letters
SN - 0366-7022
IS - 2
ER -