Extraordinary microwave effect on atropo-enantioselective catalytic reduction of biaryl lactones

Kazuya Nushiro, Satoshi Kikuchi, Tohru Yamada

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

It was found that microwave irradiation under strictly controlled temperature conditions drastically enhanced the catalytic atropo- enantioselective CoreyBakshiShibata (CBS) reduction of biaryl lactones. Since the high enantioselectivity was maintained completely compared with conventional heating conditions, the present enhancement is not caused by simple microwave heating. It was also revealed that the microwave irradiation could accelerate the racemization of the atropoenantiomers of optically active biaryl lactone. It could be concluded that the drastic enhancement with retention of the high enantioselectivity was caused not by simple heating, but by some direct microwave effect on the substrate molecule.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalChemistry Letters
Volume42
Issue number2
DOIs
Publication statusPublished - 2013 Feb 21

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)

Cite this