Extraosseous benign notochordal cell tumor originating in the lung: A case report

Yusuke Takahashi, Toru Motoi, Masahiko Harada, Yumiko Fukuda, Tsunekazu Hishima, Hirotoshi Horio

Research output: Contribution to journalArticle

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Abstract

Benign notochordal cell tumors (BNCTs) are tumors originating in the axial skeleton, where chordomas occur. Although very rare, some cases of extraosseous chordoma, such as in the soft tissue and lungs, have been reported. We report a case of a primary tumor showing the notochordal characteristics of BNCTs within the axial skeleton.An asymptomatic 57-year-old woman presented with an abnormal shadow on her chest radiograph; chest computed tomography revealed a well-defined round nodule. The resected sample tissue contained a jelly-like small nodule. Histologically, it was identified as a BNCT, based on minimal nuclear atypia, extremely low mitotic activity within the tumor cells lying in a sheet-like arrangement, and focal immunopositivity for brachyury.This is the third case report of BNCT originating in the lungs; BNCTs are considered asymptomatic tumors that are identified by using highly developed chest imaging technology; however, our findings also suggest that these notochordal tumors may potentially originate from extraosseous sites that lack ideal precursor cells. Our case suggests that notochordal tumors can arise from organs that are unrelated to known notochordal development.

Original languageEnglish
Pages (from-to)e366
JournalMedicine (United States)
Volume94
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Lung
Neoplasms
Chordoma
Thorax
Skeleton
Tomography
Technology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Takahashi, Y., Motoi, T., Harada, M., Fukuda, Y., Hishima, T., & Horio, H. (2015). Extraosseous benign notochordal cell tumor originating in the lung: A case report. Medicine (United States), 94(1), e366. https://doi.org/10.1097/MD.0000000000000366

Extraosseous benign notochordal cell tumor originating in the lung : A case report. / Takahashi, Yusuke; Motoi, Toru; Harada, Masahiko; Fukuda, Yumiko; Hishima, Tsunekazu; Horio, Hirotoshi.

In: Medicine (United States), Vol. 94, No. 1, 01.01.2015, p. e366.

Research output: Contribution to journalArticle

Takahashi, Y, Motoi, T, Harada, M, Fukuda, Y, Hishima, T & Horio, H 2015, 'Extraosseous benign notochordal cell tumor originating in the lung: A case report', Medicine (United States), vol. 94, no. 1, pp. e366. https://doi.org/10.1097/MD.0000000000000366
Takahashi, Yusuke ; Motoi, Toru ; Harada, Masahiko ; Fukuda, Yumiko ; Hishima, Tsunekazu ; Horio, Hirotoshi. / Extraosseous benign notochordal cell tumor originating in the lung : A case report. In: Medicine (United States). 2015 ; Vol. 94, No. 1. pp. e366.
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