Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection

Akane Suzuki, Tribidasari A. Ivandini, Kenji Yoshimi, Akira Fujishima, Genko Oyama, Taizo Nakazato, Nobutaka Hattori, Shigeru Kitazawa, Yasuaki Einaga

Research output: Contribution to journalArticle

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Abstract

Highly boron-doped diamond (BDD) was deposited on chemically etched micrometer-sized tungsten wires using microwave plasma assisted chemical vapor deposition (MPCVD), and these were used to fabricate BDD microelectrodes. BDD microelectrodes with very small diameter (about 5 μm) and 250 μm in length could be made successfully. In addition to the unique properties of BDD electrodes, such as a very low background current, high stability, and selective oxidation of dopamine (DA) in the presence of ascorbic acid (AA), other superior properties of the microelectrodes, including a constant current response, an increase in the mass transport, and the ability for use in high resistance media were also shown. An application study was conducted for in vivo detection of DA in mouse brain, where the BDD microelectrode was inserted into the corpus striatum of the mouse brain. A clear signal current response following medial forebrain bundle (MFB) stimulation could be obtained with high sensitivity. Excellent stability was achieved, indicating that the BDD microelectrodes are very promising for future in vivo electroanalysis.

Original languageEnglish
Pages (from-to)8608-8615
Number of pages8
JournalAnalytical Chemistry
Volume79
Issue number22
DOIs
Publication statusPublished - 2007 Nov 15

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Diamond
Boron
Microelectrodes
Dopamine
Fabrication
Brain
Tungsten
Ascorbic Acid
Chemical vapor deposition
Mass transfer
Microwaves
Wire
Plasmas
Oxidation
Electrodes

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection. / Suzuki, Akane; Ivandini, Tribidasari A.; Yoshimi, Kenji; Fujishima, Akira; Oyama, Genko; Nakazato, Taizo; Hattori, Nobutaka; Kitazawa, Shigeru; Einaga, Yasuaki.

In: Analytical Chemistry, Vol. 79, No. 22, 15.11.2007, p. 8608-8615.

Research output: Contribution to journalArticle

Suzuki, A, Ivandini, TA, Yoshimi, K, Fujishima, A, Oyama, G, Nakazato, T, Hattori, N, Kitazawa, S & Einaga, Y 2007, 'Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection', Analytical Chemistry, vol. 79, no. 22, pp. 8608-8615. https://doi.org/10.1021/ac071519h
Suzuki, Akane ; Ivandini, Tribidasari A. ; Yoshimi, Kenji ; Fujishima, Akira ; Oyama, Genko ; Nakazato, Taizo ; Hattori, Nobutaka ; Kitazawa, Shigeru ; Einaga, Yasuaki. / Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection. In: Analytical Chemistry. 2007 ; Vol. 79, No. 22. pp. 8608-8615.
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AU - Oyama, Genko

AU - Nakazato, Taizo

AU - Hattori, Nobutaka

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