Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Maria Leilani Torres-Mapa, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

    Original languageEnglish
    Article number4333
    JournalSensors (Switzerland)
    Volume19
    Issue number19
    DOIs
    Publication statusPublished - 2019 Oct 1

      Fingerprint

    Keywords

    • 3D printing
    • Fluorescence
    • Hydrogels
    • Microfluidics
    • Waveguide

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Atomic and Molecular Physics, and Optics
    • Instrumentation
    • Electrical and Electronic Engineering

    Cite this

    Torres-Mapa, M. L., Singh, M., Simon, O., Mapa, J. L., Machida, M., Günther, A., Roth, B., Heinemann, D., Terakawa, M., & Heisterkamp, A. (2019). Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing. Sensors (Switzerland), 19(19), [4333]. https://doi.org/10.3390/s19194333