Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Maria Leilani Torres-Mapa, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

Original languageEnglish
Article number4333
JournalSensors (Switzerland)
Volume19
Issue number19
DOIs
Publication statusPublished - 2019 Oct 1

Fingerprint

Lab-on-a-chip
Hydrogel
Hydrogels
Waveguides
platforms
chips
lab-on-a-chip devices
Lab-On-A-Chip Devices
waveguides
Fabrication
Equipment and Supplies
fabrication
Fluorescence
Microfluidics
Polyethylene glycols
glycols
polyethylenes
fluorescence
microfluidic devices
biocompatibility

Keywords

  • 3D printing
  • Fluorescence
  • Hydrogels
  • Microfluidics
  • Waveguide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Torres-Mapa, M. L., Singh, M., Simon, O., Mapa, J. L., Machida, M., Günther, A., ... Heisterkamp, A. (2019). Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing. Sensors (Switzerland), 19(19), [4333]. https://doi.org/10.3390/s19194333

Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing. / Torres-Mapa, Maria Leilani; Singh, Manmeet; Simon, Olga; Mapa, Jose Louise; Machida, Manan; Günther, Axel; Roth, Bernhard; Heinemann, Dag; Terakawa, Mitsuhiro; Heisterkamp, Alexander.

In: Sensors (Switzerland), Vol. 19, No. 19, 4333, 01.10.2019.

Research output: Contribution to journalArticle

Torres-Mapa, ML, Singh, M, Simon, O, Mapa, JL, Machida, M, Günther, A, Roth, B, Heinemann, D, Terakawa, M & Heisterkamp, A 2019, 'Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing', Sensors (Switzerland), vol. 19, no. 19, 4333. https://doi.org/10.3390/s19194333
Torres-Mapa, Maria Leilani ; Singh, Manmeet ; Simon, Olga ; Mapa, Jose Louise ; Machida, Manan ; Günther, Axel ; Roth, Bernhard ; Heinemann, Dag ; Terakawa, Mitsuhiro ; Heisterkamp, Alexander. / Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing. In: Sensors (Switzerland). 2019 ; Vol. 19, No. 19.
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