Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Maria Leilani Torres-Mapa, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

Original languageEnglish
Article number4333
JournalSensors (Switzerland)
Volume19
Issue number19
DOIs
Publication statusPublished - 2019 Oct 1

Keywords

  • 3D printing
  • Fluorescence
  • Hydrogels
  • Microfluidics
  • Waveguide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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  • Cite this

    Torres-Mapa, M. L., Singh, M., Simon, O., Mapa, J. L., Machida, M., Günther, A., Roth, B., Heinemann, D., Terakawa, M., & Heisterkamp, A. (2019). Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing. Sensors (Switzerland), 19(19), [4333]. https://doi.org/10.3390/s19194333