Fabrication of paper-based analytical devices optimized by central composite design

Vahid Hamedpour, Riccardo Leardi, Koji Suzuki, Daniel Citterio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this work, an application of a design of experiments approach for the optimization of an isoniazid assay on a single-area inkjet-printed paper-based analytical device (PAD) is described. For this purpose, a central composite design was used for evaluation of the effect of device geometry and amount of assay reagents on the efficiency of the proposed device. The factors of interest were printed length, width, and sampling volume as factors related to device geometry, and amounts of the assay reagents polyvinyl alcohol (PVA), NH4OH, and AgNO3. Deposition of the assay reagents was performed by a thermal inkjet printer. The colorimetric assay mechanism of this device is based on the chemical interaction of isoniazid, ammonium hydroxide, and PVA with silver ions to induce the formation of yellow silver nanoparticles (AgNPs). The in situ-formed AgNPs can be easily detected by the naked eye or with a simple flat-bed scanner. Under optimal conditions, the calibration curve was linear in the isoniazid concentration range 0.03-10 mmol L-1 with a relative standard deviation of 3.4% (n = 5 for determination of 1.0 mmol L-1). Finally, the application of the proposed device for isoniazid determination in pharmaceutical preparations produced satisfactory results.

Original languageEnglish
Pages (from-to)2102-2108
Number of pages7
JournalAnalyst
Volume143
Issue number9
DOIs
Publication statusPublished - 2018 May 7

Fingerprint

Isoniazid
Assays
assay
Fabrication
Equipment and Supplies
Composite materials
Polyvinyl Alcohol
Polyvinyl alcohols
Silver
alcohol
silver
Ammonium Hydroxide
Ammonium hydroxide
geometry
Geometry
scanner
Design of experiments
Drug products
hydroxide
drug

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Fabrication of paper-based analytical devices optimized by central composite design. / Hamedpour, Vahid; Leardi, Riccardo; Suzuki, Koji; Citterio, Daniel.

In: Analyst, Vol. 143, No. 9, 07.05.2018, p. 2102-2108.

Research output: Contribution to journalArticle

Hamedpour, Vahid ; Leardi, Riccardo ; Suzuki, Koji ; Citterio, Daniel. / Fabrication of paper-based analytical devices optimized by central composite design. In: Analyst. 2018 ; Vol. 143, No. 9. pp. 2102-2108.
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