Factors affecting local progression after percutaneous cryoablation of lung tumors

Hideki Yashiro, Seishi Nakatsuka, Masanori Inoue, Masafumi Kawamura, Norimasa Tsukada, Keisuke Asakura, Yoshikane Yamauchi, Kohei Hashimoto, Sachio Kuribayashi

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Abstract

Purpose: To evaluate factors predicting local tumor progression after percutaneous cryoablation of lung tumors (PCLT). Materials and Methods: Seventy-one consecutive patients with 210 tumors (11 primary and 199 metastatic pulmonary neoplasms; mean maximum diameter, 12.8 mm) were treated with 102 sessions of PCLT. Rates of local tumor progression and technique effectiveness were estimated by Kaplan-Meier method. Multiple variables were evaluated with the log-rank test, followed by uni- and multivariate multilevel analyses to identify independent risk factors, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. All statistical tests were two-sided. Results: Median follow-up period was 454 days (range, 79-2,467 d). Local tumor progression occurred in 50 tumors (23.8%). One-, 2-, and 3-year local progression-free rates were 80.4%, 69.0%, and 67.7%, respectively, and technique effectiveness rates were 91.4%, 83.0%, and 83.0%, respectively. Existence of a thick vessel (diameter≥3 mm) no more than 3 mm from the edge of the tumor was assessed as an independent factor (HR, 3.84; 95% CI, 1.59-9.30; P =.003) associated with local progression by multivariate analysis. Conclusions: Presence of a vessel at least 3 mm in diameter close to the tumor represents an independent risk factor for local progression after PCLT.

Original languageEnglish
Pages (from-to)813-821
Number of pages9
JournalJournal of Vascular and Interventional Radiology
Volume24
Issue number6
DOIs
Publication statusPublished - 2013 Jun

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Cryosurgery
Lung
Neoplasms
Multivariate Analysis
Confidence Intervals
Multilevel Analysis
Lung Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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Factors affecting local progression after percutaneous cryoablation of lung tumors. / Yashiro, Hideki; Nakatsuka, Seishi; Inoue, Masanori; Kawamura, Masafumi; Tsukada, Norimasa; Asakura, Keisuke; Yamauchi, Yoshikane; Hashimoto, Kohei; Kuribayashi, Sachio.

In: Journal of Vascular and Interventional Radiology, Vol. 24, No. 6, 06.2013, p. 813-821.

Research output: Contribution to journalArticle

Yashiro, H, Nakatsuka, S, Inoue, M, Kawamura, M, Tsukada, N, Asakura, K, Yamauchi, Y, Hashimoto, K & Kuribayashi, S 2013, 'Factors affecting local progression after percutaneous cryoablation of lung tumors', Journal of Vascular and Interventional Radiology, vol. 24, no. 6, pp. 813-821. https://doi.org/10.1016/j.jvir.2012.12.026
Yashiro, Hideki ; Nakatsuka, Seishi ; Inoue, Masanori ; Kawamura, Masafumi ; Tsukada, Norimasa ; Asakura, Keisuke ; Yamauchi, Yoshikane ; Hashimoto, Kohei ; Kuribayashi, Sachio. / Factors affecting local progression after percutaneous cryoablation of lung tumors. In: Journal of Vascular and Interventional Radiology. 2013 ; Vol. 24, No. 6. pp. 813-821.
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AB - Purpose: To evaluate factors predicting local tumor progression after percutaneous cryoablation of lung tumors (PCLT). Materials and Methods: Seventy-one consecutive patients with 210 tumors (11 primary and 199 metastatic pulmonary neoplasms; mean maximum diameter, 12.8 mm) were treated with 102 sessions of PCLT. Rates of local tumor progression and technique effectiveness were estimated by Kaplan-Meier method. Multiple variables were evaluated with the log-rank test, followed by uni- and multivariate multilevel analyses to identify independent risk factors, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. All statistical tests were two-sided. Results: Median follow-up period was 454 days (range, 79-2,467 d). Local tumor progression occurred in 50 tumors (23.8%). One-, 2-, and 3-year local progression-free rates were 80.4%, 69.0%, and 67.7%, respectively, and technique effectiveness rates were 91.4%, 83.0%, and 83.0%, respectively. Existence of a thick vessel (diameter≥3 mm) no more than 3 mm from the edge of the tumor was assessed as an independent factor (HR, 3.84; 95% CI, 1.59-9.30; P =.003) associated with local progression by multivariate analysis. Conclusions: Presence of a vessel at least 3 mm in diameter close to the tumor represents an independent risk factor for local progression after PCLT.

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