Abstract
Introduction. There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods. We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m2. eGFR strata were defined by baseline eGFR value as follows: stratum 1: ≥90, stratum 2: ≥60, <90, and stratum 3: ≥30, <60. Results. The annual eGFR decline was 2.3 ± 5.4 mL/min/1.73 m2 in overall subjects. Multiple linear regression analysis demonstrated that age, male sex, systolic blood pressure, logarithmically transformed albumin excretion rate (AER), eGFR strata, and hemoglobin concentration were significantly correlated with the annual eGFR decline. When stratified by eGFR, the factors that showed a significant correlation were different among eGFR strata. AER was significantly correlated with annual eGFR decline in all eGFR strata. Hemoglobin concentration showed a significant correlation only in the advanced eGFR stratum. Conclusion. The factors correlated with the annual eGFR decline were different among eGFR strata in type 2 diabetes mellitus, and hemoglobin concentration and AER were important factors for renal deterioration, especially in the advanced eGFR stratum.
| Original language | English |
|---|---|
| Article number | 687867 |
| Journal | International Journal of Endocrinology |
| Volume | 2012 |
| DOIs | |
| Publication status | Published - 2012 |
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ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Factors associated with the decline of kidney function differ among eGFR strata in subjects with type 2 diabetes mellitus. / Meguro, Shu; Tomita, Masuomi; Kabeya, Yusuke; Katsuki, Takeshi; Oikawa, Yoichi; Shimada, Akira; Kawai, Toshihide; Itoh, Hiroshi; Atsumi, Yoshihito.
In: International Journal of Endocrinology, Vol. 2012, 687867, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors associated with the decline of kidney function differ among eGFR strata in subjects with type 2 diabetes mellitus
AU - Meguro, Shu
AU - Tomita, Masuomi
AU - Kabeya, Yusuke
AU - Katsuki, Takeshi
AU - Oikawa, Yoichi
AU - Shimada, Akira
AU - Kawai, Toshihide
AU - Itoh, Hiroshi
AU - Atsumi, Yoshihito
PY - 2012
Y1 - 2012
N2 - Introduction. There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods. We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m2. eGFR strata were defined by baseline eGFR value as follows: stratum 1: ≥90, stratum 2: ≥60, <90, and stratum 3: ≥30, <60. Results. The annual eGFR decline was 2.3 ± 5.4 mL/min/1.73 m2 in overall subjects. Multiple linear regression analysis demonstrated that age, male sex, systolic blood pressure, logarithmically transformed albumin excretion rate (AER), eGFR strata, and hemoglobin concentration were significantly correlated with the annual eGFR decline. When stratified by eGFR, the factors that showed a significant correlation were different among eGFR strata. AER was significantly correlated with annual eGFR decline in all eGFR strata. Hemoglobin concentration showed a significant correlation only in the advanced eGFR stratum. Conclusion. The factors correlated with the annual eGFR decline were different among eGFR strata in type 2 diabetes mellitus, and hemoglobin concentration and AER were important factors for renal deterioration, especially in the advanced eGFR stratum.
AB - Introduction. There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods. We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m2. eGFR strata were defined by baseline eGFR value as follows: stratum 1: ≥90, stratum 2: ≥60, <90, and stratum 3: ≥30, <60. Results. The annual eGFR decline was 2.3 ± 5.4 mL/min/1.73 m2 in overall subjects. Multiple linear regression analysis demonstrated that age, male sex, systolic blood pressure, logarithmically transformed albumin excretion rate (AER), eGFR strata, and hemoglobin concentration were significantly correlated with the annual eGFR decline. When stratified by eGFR, the factors that showed a significant correlation were different among eGFR strata. AER was significantly correlated with annual eGFR decline in all eGFR strata. Hemoglobin concentration showed a significant correlation only in the advanced eGFR stratum. Conclusion. The factors correlated with the annual eGFR decline were different among eGFR strata in type 2 diabetes mellitus, and hemoglobin concentration and AER were important factors for renal deterioration, especially in the advanced eGFR stratum.
UR - http://www.scopus.com/inward/record.url?scp=84872145165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872145165&partnerID=8YFLogxK
U2 - 10.1155/2012/687867
DO - 10.1155/2012/687867
M3 - Article
C2 - 23316229
AN - SCOPUS:84872145165
VL - 2012
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
SN - 1687-8337
M1 - 687867
ER -