Factors influencing survival of patients undergoing hepatectomy for colorectal metastases

J. Yamamoto, K. Shimada, T. Kosuge, S. Yamasaki, Michiie Sakamoto, H. Fukuda

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Background: The extent of surgical margin is still a matter of controversy with regard to outcome after liver resection for metastatic disease. The aim of this study was to clarify the significant prognostic factors after hepatectomy for colorectal metastases, with special reference to the surgical margin. Methods: Ninety-six patients who underwent initial hepatic resection for liver metastases from colorectal cancer between 1992 and 1994 were studied. Results: Overall 1-, 3- and 5-year survival rates were 94, 61 and 51 per cent respectively. All of the independent factors associated with poor prognosis after hepatic resection were tumour-related factors, such as the number of tumours (four or more), presence of portal vein invasion, hepatic vein invasion and absence of a fibrous pseudocapsule. A. positive resection margin was not an independent prognostic factor, because of its strong relationship with the number of rumours resected. Conclusion: A generous surgical margin is not essential for curative hepatic resection, although positive surgical margins should be avoided. New potential risk factors which affect survival, such as the presence of portal vein or hepatic vein invasion and the absence of a pseudocapsule, may be helpful for defining the indications for postoperative adjuvant treatment.

Original languageEnglish
Pages (from-to)332-337
Number of pages6
JournalBritish Journal of Surgery
Volume86
Issue number3
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Hepatectomy
Neoplasm Metastasis
Survival
Liver
Hepatic Veins
Portal Vein
Colorectal Neoplasms
Neoplasms
Survival Rate
Margins of Excision

ASJC Scopus subject areas

  • Surgery

Cite this

Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. / Yamamoto, J.; Shimada, K.; Kosuge, T.; Yamasaki, S.; Sakamoto, Michiie; Fukuda, H.

In: British Journal of Surgery, Vol. 86, No. 3, 1999, p. 332-337.

Research output: Contribution to journalArticle

Yamamoto, J. ; Shimada, K. ; Kosuge, T. ; Yamasaki, S. ; Sakamoto, Michiie ; Fukuda, H. / Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. In: British Journal of Surgery. 1999 ; Vol. 86, No. 3. pp. 332-337.
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AU - Fukuda, H.

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