Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection

A retrospective analysis

Itsuko Asada-Hirayama, Shinya Kodashima, Osamu Goto, Nobutake Yamamichi, Satoshi Ono, Keiko Niimi, Satoshi Mochizuki, Maki Konno-Shimizu, Rie Mikami-Matsuda, Chihiro Minatsuki, Yu Takahashi, Keisuke Matsusaka, Tetsuo Ushiku, Masashi Fukayama, Mitsuhiro Fujishiro, Kazuhiko Koike

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Certain tumor characteristics may pose challenges when endoscopically determining the horizontal extent of early gastric cancers (EGC). In the present study, clinicopathological features related to inaccurate endoscopic evaluation of horizontal extent of intestinal-type EGC were analyzed. Patients and Methods We analyzed 431 lesions with intestinal-type EGC treated by endoscopic submucosal dissection (ESD) at our hospital. We focused on whether pretreatment demarcation was accurate by comparing positional relationships between marking dots and tumor edges in resected specimens, and factors related to inaccurate evaluation were analyzed. Gender, age, tumor size, location, circumference, depth, ulceration, macroscopic type, presence of a flat (0-IIb) component, predominant histological type, mixture of diffuse-type adenocarcinoma, mixed histology, and use of magnification endoscopy with narrow band imaging were analyzed. Reasons for inaccurate evaluation were also investigated by re-examining endoscopic images and prepared histological slides. Results Rate of inaccurate evaluation of horizontal extent was 7.4% (32/431 lesions). Multivariate analysis revealed the following significant independent variables contributing to inaccurate endoscopic evaluation: presence of a flat component, large size, and predominant histological findings of moderately differentiated adenocarcinoma. Re-examination of prepared histological slides of inaccurately evaluated cases revealed a marginal flat spreading area in 28 of the 32 lesions (87.5%). In 14 of the 32 lesions (43.8%), tumor margins were composed of moderately differentiated adenocarcinoma. Conclusions For lesions with a flat component, large lesions, and moderately differentiated adenocarcinoma, determination of the horizontal extent can be challenging in EGC indicated for ESD, even with the best available endoscopic tools.

Original languageEnglish
Pages (from-to)593-600
Number of pages8
JournalDigestive Endoscopy
Volume25
Issue number6
DOIs
Publication statusPublished - 2013 Nov

Fingerprint

Stomach Neoplasms
Adenocarcinoma
Neoplasms
Narrow Band Imaging
Endoscopy
Histology
Multivariate Analysis
Endoscopic Mucosal Resection

Keywords

  • early gastric cancer (EGC)
  • endoscopic submucosal dissection (ESD)
  • horizontal extent
  • inaccurate demarcation
  • marking dots

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection : A retrospective analysis. / Asada-Hirayama, Itsuko; Kodashima, Shinya; Goto, Osamu; Yamamichi, Nobutake; Ono, Satoshi; Niimi, Keiko; Mochizuki, Satoshi; Konno-Shimizu, Maki; Mikami-Matsuda, Rie; Minatsuki, Chihiro; Takahashi, Yu; Matsusaka, Keisuke; Ushiku, Tetsuo; Fukayama, Masashi; Fujishiro, Mitsuhiro; Koike, Kazuhiko.

In: Digestive Endoscopy, Vol. 25, No. 6, 11.2013, p. 593-600.

Research output: Contribution to journalArticle

Asada-Hirayama, I, Kodashima, S, Goto, O, Yamamichi, N, Ono, S, Niimi, K, Mochizuki, S, Konno-Shimizu, M, Mikami-Matsuda, R, Minatsuki, C, Takahashi, Y, Matsusaka, K, Ushiku, T, Fukayama, M, Fujishiro, M & Koike, K 2013, 'Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis', Digestive Endoscopy, vol. 25, no. 6, pp. 593-600. https://doi.org/10.1111/den.12043
Asada-Hirayama, Itsuko ; Kodashima, Shinya ; Goto, Osamu ; Yamamichi, Nobutake ; Ono, Satoshi ; Niimi, Keiko ; Mochizuki, Satoshi ; Konno-Shimizu, Maki ; Mikami-Matsuda, Rie ; Minatsuki, Chihiro ; Takahashi, Yu ; Matsusaka, Keisuke ; Ushiku, Tetsuo ; Fukayama, Masashi ; Fujishiro, Mitsuhiro ; Koike, Kazuhiko. / Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection : A retrospective analysis. In: Digestive Endoscopy. 2013 ; Vol. 25, No. 6. pp. 593-600.
@article{e579c4a8b7a945a3af1fd392a98c52dd,
title = "Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis",
abstract = "Background Certain tumor characteristics may pose challenges when endoscopically determining the horizontal extent of early gastric cancers (EGC). In the present study, clinicopathological features related to inaccurate endoscopic evaluation of horizontal extent of intestinal-type EGC were analyzed. Patients and Methods We analyzed 431 lesions with intestinal-type EGC treated by endoscopic submucosal dissection (ESD) at our hospital. We focused on whether pretreatment demarcation was accurate by comparing positional relationships between marking dots and tumor edges in resected specimens, and factors related to inaccurate evaluation were analyzed. Gender, age, tumor size, location, circumference, depth, ulceration, macroscopic type, presence of a flat (0-IIb) component, predominant histological type, mixture of diffuse-type adenocarcinoma, mixed histology, and use of magnification endoscopy with narrow band imaging were analyzed. Reasons for inaccurate evaluation were also investigated by re-examining endoscopic images and prepared histological slides. Results Rate of inaccurate evaluation of horizontal extent was 7.4{\%} (32/431 lesions). Multivariate analysis revealed the following significant independent variables contributing to inaccurate endoscopic evaluation: presence of a flat component, large size, and predominant histological findings of moderately differentiated adenocarcinoma. Re-examination of prepared histological slides of inaccurately evaluated cases revealed a marginal flat spreading area in 28 of the 32 lesions (87.5{\%}). In 14 of the 32 lesions (43.8{\%}), tumor margins were composed of moderately differentiated adenocarcinoma. Conclusions For lesions with a flat component, large lesions, and moderately differentiated adenocarcinoma, determination of the horizontal extent can be challenging in EGC indicated for ESD, even with the best available endoscopic tools.",
keywords = "early gastric cancer (EGC), endoscopic submucosal dissection (ESD), horizontal extent, inaccurate demarcation, marking dots",
author = "Itsuko Asada-Hirayama and Shinya Kodashima and Osamu Goto and Nobutake Yamamichi and Satoshi Ono and Keiko Niimi and Satoshi Mochizuki and Maki Konno-Shimizu and Rie Mikami-Matsuda and Chihiro Minatsuki and Yu Takahashi and Keisuke Matsusaka and Tetsuo Ushiku and Masashi Fukayama and Mitsuhiro Fujishiro and Kazuhiko Koike",
year = "2013",
month = "11",
doi = "10.1111/den.12043",
language = "English",
volume = "25",
pages = "593--600",
journal = "Digestive Endoscopy",
issn = "0915-5635",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection

T2 - A retrospective analysis

AU - Asada-Hirayama, Itsuko

AU - Kodashima, Shinya

AU - Goto, Osamu

AU - Yamamichi, Nobutake

AU - Ono, Satoshi

AU - Niimi, Keiko

AU - Mochizuki, Satoshi

AU - Konno-Shimizu, Maki

AU - Mikami-Matsuda, Rie

AU - Minatsuki, Chihiro

AU - Takahashi, Yu

AU - Matsusaka, Keisuke

AU - Ushiku, Tetsuo

AU - Fukayama, Masashi

AU - Fujishiro, Mitsuhiro

AU - Koike, Kazuhiko

PY - 2013/11

Y1 - 2013/11

N2 - Background Certain tumor characteristics may pose challenges when endoscopically determining the horizontal extent of early gastric cancers (EGC). In the present study, clinicopathological features related to inaccurate endoscopic evaluation of horizontal extent of intestinal-type EGC were analyzed. Patients and Methods We analyzed 431 lesions with intestinal-type EGC treated by endoscopic submucosal dissection (ESD) at our hospital. We focused on whether pretreatment demarcation was accurate by comparing positional relationships between marking dots and tumor edges in resected specimens, and factors related to inaccurate evaluation were analyzed. Gender, age, tumor size, location, circumference, depth, ulceration, macroscopic type, presence of a flat (0-IIb) component, predominant histological type, mixture of diffuse-type adenocarcinoma, mixed histology, and use of magnification endoscopy with narrow band imaging were analyzed. Reasons for inaccurate evaluation were also investigated by re-examining endoscopic images and prepared histological slides. Results Rate of inaccurate evaluation of horizontal extent was 7.4% (32/431 lesions). Multivariate analysis revealed the following significant independent variables contributing to inaccurate endoscopic evaluation: presence of a flat component, large size, and predominant histological findings of moderately differentiated adenocarcinoma. Re-examination of prepared histological slides of inaccurately evaluated cases revealed a marginal flat spreading area in 28 of the 32 lesions (87.5%). In 14 of the 32 lesions (43.8%), tumor margins were composed of moderately differentiated adenocarcinoma. Conclusions For lesions with a flat component, large lesions, and moderately differentiated adenocarcinoma, determination of the horizontal extent can be challenging in EGC indicated for ESD, even with the best available endoscopic tools.

AB - Background Certain tumor characteristics may pose challenges when endoscopically determining the horizontal extent of early gastric cancers (EGC). In the present study, clinicopathological features related to inaccurate endoscopic evaluation of horizontal extent of intestinal-type EGC were analyzed. Patients and Methods We analyzed 431 lesions with intestinal-type EGC treated by endoscopic submucosal dissection (ESD) at our hospital. We focused on whether pretreatment demarcation was accurate by comparing positional relationships between marking dots and tumor edges in resected specimens, and factors related to inaccurate evaluation were analyzed. Gender, age, tumor size, location, circumference, depth, ulceration, macroscopic type, presence of a flat (0-IIb) component, predominant histological type, mixture of diffuse-type adenocarcinoma, mixed histology, and use of magnification endoscopy with narrow band imaging were analyzed. Reasons for inaccurate evaluation were also investigated by re-examining endoscopic images and prepared histological slides. Results Rate of inaccurate evaluation of horizontal extent was 7.4% (32/431 lesions). Multivariate analysis revealed the following significant independent variables contributing to inaccurate endoscopic evaluation: presence of a flat component, large size, and predominant histological findings of moderately differentiated adenocarcinoma. Re-examination of prepared histological slides of inaccurately evaluated cases revealed a marginal flat spreading area in 28 of the 32 lesions (87.5%). In 14 of the 32 lesions (43.8%), tumor margins were composed of moderately differentiated adenocarcinoma. Conclusions For lesions with a flat component, large lesions, and moderately differentiated adenocarcinoma, determination of the horizontal extent can be challenging in EGC indicated for ESD, even with the best available endoscopic tools.

KW - early gastric cancer (EGC)

KW - endoscopic submucosal dissection (ESD)

KW - horizontal extent

KW - inaccurate demarcation

KW - marking dots

UR - http://www.scopus.com/inward/record.url?scp=84887026507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887026507&partnerID=8YFLogxK

U2 - 10.1111/den.12043

DO - 10.1111/den.12043

M3 - Article

VL - 25

SP - 593

EP - 600

JO - Digestive Endoscopy

JF - Digestive Endoscopy

SN - 0915-5635

IS - 6

ER -