Failure in resection of multiple pulmonary metastases from colorectal cancer

Tokujiro Yano, Yasuro Fukuyama, Hideki Yokoyama, Yuichi Tanaka, Jun Miyagi, Shinji Kuninaka, Hiroshi Asoh, Yukito Ichinose

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: To clarify whether or not multiple pulmonary metastases from colorectal cancer are contraindicated for a surgical resection, we retrospectively evaluated the influence of the number of pulmonary metastases on both the postthoracotomy survival and the pattern of the first failure. Methods: From 1981 to 1993, 36 patients underwent a complete resection for pulmonary metastases from colorectal cancer. Results: Of the various factors investigated including gender, primary site, disease-free interval, tumor size, the number of metastases, type of resection, and the history of hepatic metastases, only the number of pulmonary metastases was found to be significantly related to postthoracotomy survival. The rate of disease-free survival at 5 years was 62% for solitary metastasis (n = 17), 35% for two metastases (n = 8), and 0% for four or more metastases (n = 11). The pattern of failure also differed according to the number of pulmonary metastases. In particular, the incidence of local recurrence at the primary site increased with the number of pulmonary metastases (ie, 1 of 17 patients with a solitary metastasis, 3 of 8 with two metastases, and 6 of 11 with four or more metastases). Conclusions: These results suggest that multiple metastases might indicate the presence of local recurrence at the primary site; therefore, in cases of multiple pulmonary metastases, the primary site should be thoroughly explored.

Original languageEnglish
Pages (from-to)120-122
Number of pages3
JournalJournal of the American College of Surgeons
Volume185
Issue number2
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Colorectal Neoplasms
Neoplasm Metastasis
Lung
Recurrence
Survival
Disease-Free Survival
History

ASJC Scopus subject areas

  • Surgery

Cite this

Yano, T., Fukuyama, Y., Yokoyama, H., Tanaka, Y., Miyagi, J., Kuninaka, S., ... Ichinose, Y. (1997). Failure in resection of multiple pulmonary metastases from colorectal cancer. Journal of the American College of Surgeons, 185(2), 120-122. https://doi.org/10.1016/S1072-7515(97)00032-X

Failure in resection of multiple pulmonary metastases from colorectal cancer. / Yano, Tokujiro; Fukuyama, Yasuro; Yokoyama, Hideki; Tanaka, Yuichi; Miyagi, Jun; Kuninaka, Shinji; Asoh, Hiroshi; Ichinose, Yukito.

In: Journal of the American College of Surgeons, Vol. 185, No. 2, 1997, p. 120-122.

Research output: Contribution to journalArticle

Yano, T, Fukuyama, Y, Yokoyama, H, Tanaka, Y, Miyagi, J, Kuninaka, S, Asoh, H & Ichinose, Y 1997, 'Failure in resection of multiple pulmonary metastases from colorectal cancer', Journal of the American College of Surgeons, vol. 185, no. 2, pp. 120-122. https://doi.org/10.1016/S1072-7515(97)00032-X
Yano, Tokujiro ; Fukuyama, Yasuro ; Yokoyama, Hideki ; Tanaka, Yuichi ; Miyagi, Jun ; Kuninaka, Shinji ; Asoh, Hiroshi ; Ichinose, Yukito. / Failure in resection of multiple pulmonary metastases from colorectal cancer. In: Journal of the American College of Surgeons. 1997 ; Vol. 185, No. 2. pp. 120-122.
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