False negative cases of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging in small lung cancer less than 3 cm in size

Kenichi Watanabe, Hiroaki Nomori, Takashi Ohtsuka, Tsuguo Naruke, Kimiichi Uno

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A considerable number of false negative cases in FDG-PET were seen in small-cell lung cancer, despite the usefulness of this imaging modality. We investigated the correlation between FDG-PET results and the clinicopathological findings in small lung cancers less than 3 cm in size. Fifty-one consecutive cases of surgically resected small lung cancers scanned preoperatively by FDG-PET was assessed. The medical records of each case were reviewed for the maximum tumor size in the CT findings, histology, grade of differentiation, lymphatic and vascular invasion, pleural invasion, lymph node stage, serum level of carcinoembryonic antigen (CEA), and CT findings. All of the 5 cases (4 adenocarcinomas, 1 small-cell carcinoma) less than 1 cm in size were false negatives. In the 46 cases 1-3 cm in size (34 adenocarcinomas, 9 squamous sell carcinomas, 2 large sell carcinomas, 1 small cell carcinoma), false negative results were seen in 8 of 15 cases of well-differentiated adenocarcinoma (53%). In the 8 false negative cases, 1 (13%) lymphatic vessel invasion (ly), 0 (0%) vascular vessel invasion (v), 0 (0%) pleural invasion (p), 0 (0%) lymph node metastasis, 0 (0%) high serum level of CEA, and 5 (63%) cases showing ground-glass opacity on CT were observed. There were significant differences in the factors ly, v, CEA, and CT findings between the 8 false-negative cases and the 26 true positive cases with adenocarcinoma (p < 0.01-0.05). Lung cancers < 1 cm in size cannot be detected in FDG-PET. Adenocarcinomas of the lung 1-3 cm in size with false negatives in FDG-PET showed significantly less invasiveness than the true positives.

Original languageEnglish
Pages (from-to)787-793
Number of pages7
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume42
Issue number9
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Lung Neoplasms
Carcinoembryonic Antigen
Adenocarcinoma
Small Cell Carcinoma
Blood Vessels
Lymph Nodes
Lymphatic Vessels
Small Cell Lung Carcinoma
Serum
Medical Records
Glass
Squamous Cell Carcinoma
Histology
Neoplasm Metastasis
Carcinoma
Neoplasms

Cite this

False negative cases of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging in small lung cancer less than 3 cm in size. / Watanabe, Kenichi; Nomori, Hiroaki; Ohtsuka, Takashi; Naruke, Tsuguo; Uno, Kimiichi.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 42, No. 9, 2004, p. 787-793.

Research output: Contribution to journalArticle

@article{b1e06e0c063947eb90a7b292269d0b66,
title = "False negative cases of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging in small lung cancer less than 3 cm in size",
abstract = "A considerable number of false negative cases in FDG-PET were seen in small-cell lung cancer, despite the usefulness of this imaging modality. We investigated the correlation between FDG-PET results and the clinicopathological findings in small lung cancers less than 3 cm in size. Fifty-one consecutive cases of surgically resected small lung cancers scanned preoperatively by FDG-PET was assessed. The medical records of each case were reviewed for the maximum tumor size in the CT findings, histology, grade of differentiation, lymphatic and vascular invasion, pleural invasion, lymph node stage, serum level of carcinoembryonic antigen (CEA), and CT findings. All of the 5 cases (4 adenocarcinomas, 1 small-cell carcinoma) less than 1 cm in size were false negatives. In the 46 cases 1-3 cm in size (34 adenocarcinomas, 9 squamous sell carcinomas, 2 large sell carcinomas, 1 small cell carcinoma), false negative results were seen in 8 of 15 cases of well-differentiated adenocarcinoma (53{\%}). In the 8 false negative cases, 1 (13{\%}) lymphatic vessel invasion (ly), 0 (0{\%}) vascular vessel invasion (v), 0 (0{\%}) pleural invasion (p), 0 (0{\%}) lymph node metastasis, 0 (0{\%}) high serum level of CEA, and 5 (63{\%}) cases showing ground-glass opacity on CT were observed. There were significant differences in the factors ly, v, CEA, and CT findings between the 8 false-negative cases and the 26 true positive cases with adenocarcinoma (p < 0.01-0.05). Lung cancers < 1 cm in size cannot be detected in FDG-PET. Adenocarcinomas of the lung 1-3 cm in size with false negatives in FDG-PET showed significantly less invasiveness than the true positives.",
author = "Kenichi Watanabe and Hiroaki Nomori and Takashi Ohtsuka and Tsuguo Naruke and Kimiichi Uno",
year = "2004",
language = "English",
volume = "42",
pages = "787--793",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "9",

}

TY - JOUR

T1 - False negative cases of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging in small lung cancer less than 3 cm in size

AU - Watanabe, Kenichi

AU - Nomori, Hiroaki

AU - Ohtsuka, Takashi

AU - Naruke, Tsuguo

AU - Uno, Kimiichi

PY - 2004

Y1 - 2004

N2 - A considerable number of false negative cases in FDG-PET were seen in small-cell lung cancer, despite the usefulness of this imaging modality. We investigated the correlation between FDG-PET results and the clinicopathological findings in small lung cancers less than 3 cm in size. Fifty-one consecutive cases of surgically resected small lung cancers scanned preoperatively by FDG-PET was assessed. The medical records of each case were reviewed for the maximum tumor size in the CT findings, histology, grade of differentiation, lymphatic and vascular invasion, pleural invasion, lymph node stage, serum level of carcinoembryonic antigen (CEA), and CT findings. All of the 5 cases (4 adenocarcinomas, 1 small-cell carcinoma) less than 1 cm in size were false negatives. In the 46 cases 1-3 cm in size (34 adenocarcinomas, 9 squamous sell carcinomas, 2 large sell carcinomas, 1 small cell carcinoma), false negative results were seen in 8 of 15 cases of well-differentiated adenocarcinoma (53%). In the 8 false negative cases, 1 (13%) lymphatic vessel invasion (ly), 0 (0%) vascular vessel invasion (v), 0 (0%) pleural invasion (p), 0 (0%) lymph node metastasis, 0 (0%) high serum level of CEA, and 5 (63%) cases showing ground-glass opacity on CT were observed. There were significant differences in the factors ly, v, CEA, and CT findings between the 8 false-negative cases and the 26 true positive cases with adenocarcinoma (p < 0.01-0.05). Lung cancers < 1 cm in size cannot be detected in FDG-PET. Adenocarcinomas of the lung 1-3 cm in size with false negatives in FDG-PET showed significantly less invasiveness than the true positives.

AB - A considerable number of false negative cases in FDG-PET were seen in small-cell lung cancer, despite the usefulness of this imaging modality. We investigated the correlation between FDG-PET results and the clinicopathological findings in small lung cancers less than 3 cm in size. Fifty-one consecutive cases of surgically resected small lung cancers scanned preoperatively by FDG-PET was assessed. The medical records of each case were reviewed for the maximum tumor size in the CT findings, histology, grade of differentiation, lymphatic and vascular invasion, pleural invasion, lymph node stage, serum level of carcinoembryonic antigen (CEA), and CT findings. All of the 5 cases (4 adenocarcinomas, 1 small-cell carcinoma) less than 1 cm in size were false negatives. In the 46 cases 1-3 cm in size (34 adenocarcinomas, 9 squamous sell carcinomas, 2 large sell carcinomas, 1 small cell carcinoma), false negative results were seen in 8 of 15 cases of well-differentiated adenocarcinoma (53%). In the 8 false negative cases, 1 (13%) lymphatic vessel invasion (ly), 0 (0%) vascular vessel invasion (v), 0 (0%) pleural invasion (p), 0 (0%) lymph node metastasis, 0 (0%) high serum level of CEA, and 5 (63%) cases showing ground-glass opacity on CT were observed. There were significant differences in the factors ly, v, CEA, and CT findings between the 8 false-negative cases and the 26 true positive cases with adenocarcinoma (p < 0.01-0.05). Lung cancers < 1 cm in size cannot be detected in FDG-PET. Adenocarcinomas of the lung 1-3 cm in size with false negatives in FDG-PET showed significantly less invasiveness than the true positives.

UR - http://www.scopus.com/inward/record.url?scp=16544376723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16544376723&partnerID=8YFLogxK

M3 - Article

C2 - 15500145

AN - SCOPUS:16544376723

VL - 42

SP - 787

EP - 793

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 9

ER -