False-positive serology following intravenous immunoglobulin and plasma exchange through transfusion of fresh frozen plasma in a patient with pemphigus vulgaris

Hisashi Nomura, Haruki Honda, Shohei Egami, Tomoaki Yokoyama, Atsushi Fujimoto, Makiko Ishikawa, Makoto Sugiura

Research output: Contribution to journalArticle

Abstract

Intravenous immunoglobulin therapy and plasma exchange through transfusion of fresh frozen plasma are therapeutic options for patients with refractory pemphigus vulgaris. Passive acquisition of various clinically important antibodies through these therapies can occur, leading to false serology and negatively affecting patients' clinical care. It is recommended that dermatologists recognize the possibility of these phenomena and interpret them appropriately. Here, we report false-positive serology following intravenous immunoglobulin therapy and plasma exchange through transfusion of fresh frozen plasma in a patient with refractory pemphigus vulgaris. We also discuss the measure for misinterpretation and unnecessary clinical intervention.

Original languageEnglish
Pages (from-to)398-400
Number of pages3
JournalJournal of Dermatology
Volume42
Issue number4
DOIs
Publication statusPublished - 2015 Apr 1
Externally publishedYes

Fingerprint

Plasma Exchange
Passive Immunization
Pemphigus
Intravenous Immunoglobulins
Serology
Patient Care
Antibodies
Therapeutics
Dermatologists

Keywords

  • False serology
  • Fresh frozen plasma
  • Intravenous immunoglobulin
  • Pemphigus vulgaris
  • Plasma exchange

ASJC Scopus subject areas

  • Dermatology

Cite this

False-positive serology following intravenous immunoglobulin and plasma exchange through transfusion of fresh frozen plasma in a patient with pemphigus vulgaris. / Nomura, Hisashi; Honda, Haruki; Egami, Shohei; Yokoyama, Tomoaki; Fujimoto, Atsushi; Ishikawa, Makiko; Sugiura, Makoto.

In: Journal of Dermatology, Vol. 42, No. 4, 01.04.2015, p. 398-400.

Research output: Contribution to journalArticle

Nomura, Hisashi ; Honda, Haruki ; Egami, Shohei ; Yokoyama, Tomoaki ; Fujimoto, Atsushi ; Ishikawa, Makiko ; Sugiura, Makoto. / False-positive serology following intravenous immunoglobulin and plasma exchange through transfusion of fresh frozen plasma in a patient with pemphigus vulgaris. In: Journal of Dermatology. 2015 ; Vol. 42, No. 4. pp. 398-400.
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