Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection

Toshihiro Nishizawa, Hidekazu Suzuki, Kosuke Sakitani, Hiroharu Yamashita, Shuntaro Yoshida, Keisuke Hata, Takamitsu Kanazawa, Naoto Fujiwara, Takanori Kanai, Naohisa Yahagi, Osamu Toyoshima

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and aim: Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with Helicobacter pylori (H. pylori) infection. Methods: We reviewed 206 H. pylori-infected patients retrospectively. Endoscopic gastric atrophy was classified into closed- and open-type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first-degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open-type gastric atrophy. Results: On multivariate analysis, age (odds ratio = 1.079, 95% confidence interval = 1.048–1.11, p < 0.001), family history of gastric cancer (odds ratio = 3.967, 95% confidence interval = 1.414–10.6, p = 0.006) and duodenal ulcer (odds ratio = 0.834, 95% confidence interval = 0.711–0.977, p = 0.024) were the factors independently associated with open-type gastric atrophy. Conclusions: A first-degree family history of gastric cancer, absence of duodenal ulcer, and old age were independent risk factors for the progression of gastric atrophy among H. pylori-infected patients. Careful examination with upper gastrointestinal endoscopy is necessary in patients with such risk factors.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalUnited European Gastroenterology Journal
Volume5
Issue number1
DOIs
Publication statusPublished - 2017

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Helicobacter Infections
Helicobacter pylori
Atrophy
Stomach
Duodenal Ulcer
Stomach Neoplasms
Odds Ratio
Confidence Intervals
Atrophic Gastritis
Gastrointestinal Endoscopy
Stomach Ulcer
Alcohol Drinking
Body Mass Index
Multivariate Analysis
Logistic Models
Smoking
Regression Analysis
Neoplasms

Keywords

  • Atrophic gastritis
  • duodenal ulcer
  • family history
  • gastric cancer
  • H. pylori

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection. / Nishizawa, Toshihiro; Suzuki, Hidekazu; Sakitani, Kosuke; Yamashita, Hiroharu; Yoshida, Shuntaro; Hata, Keisuke; Kanazawa, Takamitsu; Fujiwara, Naoto; Kanai, Takanori; Yahagi, Naohisa; Toyoshima, Osamu.

In: United European Gastroenterology Journal, Vol. 5, No. 1, 2017, p. 32-36.

Research output: Contribution to journalArticle

Nishizawa, Toshihiro ; Suzuki, Hidekazu ; Sakitani, Kosuke ; Yamashita, Hiroharu ; Yoshida, Shuntaro ; Hata, Keisuke ; Kanazawa, Takamitsu ; Fujiwara, Naoto ; Kanai, Takanori ; Yahagi, Naohisa ; Toyoshima, Osamu. / Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection. In: United European Gastroenterology Journal. 2017 ; Vol. 5, No. 1. pp. 32-36.
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AU - Hata, Keisuke

AU - Kanazawa, Takamitsu

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