Fast spectroscopic imaging strategies for potential applications in fMRI

Robert V. Mulkern, Nan Kuei Chen, Koichi Oshio, Lawrence P. Panych, Frank J. Rybicki, Giulio Gambarota

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Technical aspects of two general fast spectroscopic imaging (SI) strategies, one based on gradient echo trains and the other on spin echo trains, are reviewed within the context of potential applications in the field of functional magnetic resonance imaging (fMRI). Fast spectroscopic imaging of water may prove useful for identifying mechanisms underlying the blood oxygenation level dependence (BOLD) of the water signal during brain activation studies. Reasonably rapid mapping of changes in proton signals from brain metabolites, like lactate, creatine or even neurotransmitter associated metabolites like GABA, is substantially more challenging but technically feasible particularly as higher field strengths become available. Fast spectroscopic methods directed towards the 31P signals from phosphocreatine (PCr) and adenosine tri-phosphates (ATP) are also technically feasible and may prove useful for studying cerebral energetics within fMRI contexts.

Original languageEnglish
Pages (from-to)1395-1405
Number of pages11
JournalMagnetic Resonance Imaging
Volume22
Issue number10 SPEC. ISS.
DOIs
Publication statusPublished - 2004 Dec
Externally publishedYes

Fingerprint

Metabolites
magnetic resonance
Brain
metabolites
Magnetic Resonance Imaging
Imaging techniques
brain
Oxygenation
Phosphocreatine
Adenine Nucleotides
Creatine
Water
echoes
creatine
Adenosine
gamma-Aminobutyric Acid
neurotransmitters
Neurotransmitter Agents
Protons
Lactic Acid

Keywords

  • ATP
  • Brain metabolites
  • Fast spectroscopic imaging
  • fMRI
  • Functional MR
  • Lactate
  • Magnetic resonance spectroscopy
  • Phosphorus
  • T2*

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Mulkern, R. V., Chen, N. K., Oshio, K., Panych, L. P., Rybicki, F. J., & Gambarota, G. (2004). Fast spectroscopic imaging strategies for potential applications in fMRI. Magnetic Resonance Imaging, 22(10 SPEC. ISS.), 1395-1405. https://doi.org/10.1016/j.mri.2004.10.011

Fast spectroscopic imaging strategies for potential applications in fMRI. / Mulkern, Robert V.; Chen, Nan Kuei; Oshio, Koichi; Panych, Lawrence P.; Rybicki, Frank J.; Gambarota, Giulio.

In: Magnetic Resonance Imaging, Vol. 22, No. 10 SPEC. ISS., 12.2004, p. 1395-1405.

Research output: Contribution to journalArticle

Mulkern, RV, Chen, NK, Oshio, K, Panych, LP, Rybicki, FJ & Gambarota, G 2004, 'Fast spectroscopic imaging strategies for potential applications in fMRI', Magnetic Resonance Imaging, vol. 22, no. 10 SPEC. ISS., pp. 1395-1405. https://doi.org/10.1016/j.mri.2004.10.011
Mulkern RV, Chen NK, Oshio K, Panych LP, Rybicki FJ, Gambarota G. Fast spectroscopic imaging strategies for potential applications in fMRI. Magnetic Resonance Imaging. 2004 Dec;22(10 SPEC. ISS.):1395-1405. https://doi.org/10.1016/j.mri.2004.10.011
Mulkern, Robert V. ; Chen, Nan Kuei ; Oshio, Koichi ; Panych, Lawrence P. ; Rybicki, Frank J. ; Gambarota, Giulio. / Fast spectroscopic imaging strategies for potential applications in fMRI. In: Magnetic Resonance Imaging. 2004 ; Vol. 22, No. 10 SPEC. ISS. pp. 1395-1405.
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