Fasting remnant lipoproteins can predict postprandial hyperlipidemia

Tomoki Nagata, Daisuke Sugiyama, Takako Kise, Satomi Tsuji, Hideo Ohira, Itsuko Sato, Mari Yamamoto, Hitomi Kohsaka, Seiji Kawano, Shizuya Yamashita, Yuichi Ishikawa, Yoshio Fujioka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients. Methods. To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19). Results: TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=-0.37, r=-0.41, r=-0.37, r=-0.36, r=-0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not. Conclusion: Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.

Original languageEnglish
Article number146
JournalLipids in Health and Disease
Volume11
DOIs
Publication statusPublished - 2012

Fingerprint

Hyperlipidemias
Lipoproteins
Fasting
Triglycerides
Apolipoproteins B
Adiponectin
Meals
Linear regression
Regression analysis
Area Under Curve
Linear Models
Regression Analysis
Hypertriglyceridemia
Apolipoprotein A-I
Waist Circumference

Keywords

  • Adiponectin.
  • Apolipoprotein B
  • Postprandial hyperlipidemia
  • Remnant lipoprotein
  • Triglyceride

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Fasting remnant lipoproteins can predict postprandial hyperlipidemia. / Nagata, Tomoki; Sugiyama, Daisuke; Kise, Takako; Tsuji, Satomi; Ohira, Hideo; Sato, Itsuko; Yamamoto, Mari; Kohsaka, Hitomi; Kawano, Seiji; Yamashita, Shizuya; Ishikawa, Yuichi; Fujioka, Yoshio.

In: Lipids in Health and Disease, Vol. 11, 146, 2012.

Research output: Contribution to journalArticle

Nagata, T, Sugiyama, D, Kise, T, Tsuji, S, Ohira, H, Sato, I, Yamamoto, M, Kohsaka, H, Kawano, S, Yamashita, S, Ishikawa, Y & Fujioka, Y 2012, 'Fasting remnant lipoproteins can predict postprandial hyperlipidemia', Lipids in Health and Disease, vol. 11, 146. https://doi.org/10.1186/1476-511X-11-146
Nagata, Tomoki ; Sugiyama, Daisuke ; Kise, Takako ; Tsuji, Satomi ; Ohira, Hideo ; Sato, Itsuko ; Yamamoto, Mari ; Kohsaka, Hitomi ; Kawano, Seiji ; Yamashita, Shizuya ; Ishikawa, Yuichi ; Fujioka, Yoshio. / Fasting remnant lipoproteins can predict postprandial hyperlipidemia. In: Lipids in Health and Disease. 2012 ; Vol. 11.
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abstract = "Background: Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients. Methods. To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19). Results: TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=-0.37, r=-0.41, r=-0.37, r=-0.36, r=-0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not. Conclusion: Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.",
keywords = "Adiponectin., Apolipoprotein B, Postprandial hyperlipidemia, Remnant lipoprotein, Triglyceride",
author = "Tomoki Nagata and Daisuke Sugiyama and Takako Kise and Satomi Tsuji and Hideo Ohira and Itsuko Sato and Mari Yamamoto and Hitomi Kohsaka and Seiji Kawano and Shizuya Yamashita and Yuichi Ishikawa and Yoshio Fujioka",
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AU - Nagata, Tomoki

AU - Sugiyama, Daisuke

AU - Kise, Takako

AU - Tsuji, Satomi

AU - Ohira, Hideo

AU - Sato, Itsuko

AU - Yamamoto, Mari

AU - Kohsaka, Hitomi

AU - Kawano, Seiji

AU - Yamashita, Shizuya

AU - Ishikawa, Yuichi

AU - Fujioka, Yoshio

PY - 2012

Y1 - 2012

N2 - Background: Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients. Methods. To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19). Results: TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=-0.37, r=-0.41, r=-0.37, r=-0.36, r=-0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not. Conclusion: Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.

AB - Background: Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients. Methods. To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19). Results: TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=-0.37, r=-0.41, r=-0.37, r=-0.36, r=-0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not. Conclusion: Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.

KW - Adiponectin.

KW - Apolipoprotein B

KW - Postprandial hyperlipidemia

KW - Remnant lipoprotein

KW - Triglyceride

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