Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: A 1H spectroscopic imaging study

Robert V. Mulkern, Jeannie Huang, Sridhar Vajapeyam, Alan B. Packard, Koichi Oshio, Steven Grinspoon

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Fat fractions and spectral T2 values of fat and water within the vertebral marrow of non-HIV- and HIV-infected men were measured with the use of a Carr-Purcell-Meiboom-Gill (CPMG) line scan spectroscopic imaging sequence. The fat fraction for the HIV-infected men (0.29 ± 0.08) was significantly lower (P < 0.05, Student's unpaired t-test) than the fat fraction found in non-HIV-infected men (0.40 ± 0.12). The mean water and fat T2 values did not differ between the two groups, and did not show any systematic dependence on fat fraction over the wide range of fat fractions encountered in this study. The marrow water and fat T2 values measured with the CPMG approach were markedly longer than the spectral T2 values reported by other groups using the more common point-resolved spectroscopy (PRESS) and stimulated-echo acquisition mode (STEAM) acquisitions. Proton spectroscopic studies of vertebral marrow revealed differences between non-HIV- and HIV-infected men that may prove useful for studying the effects of this disease and/or antiretroviral agents on body composition.

Original languageEnglish
Pages (from-to)552-558
Number of pages7
JournalMagnetic Resonance in Medicine
Volume52
Issue number3
DOIs
Publication statusPublished - 2004 Sep
Externally publishedYes

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Bone Marrow
Fats
HIV
Water
Anti-Retroviral Agents
Body Composition
Protons
Spectrum Analysis
Students

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men : A 1H spectroscopic imaging study. / Mulkern, Robert V.; Huang, Jeannie; Vajapeyam, Sridhar; Packard, Alan B.; Oshio, Koichi; Grinspoon, Steven.

In: Magnetic Resonance in Medicine, Vol. 52, No. 3, 09.2004, p. 552-558.

Research output: Contribution to journalArticle

Mulkern, Robert V. ; Huang, Jeannie ; Vajapeyam, Sridhar ; Packard, Alan B. ; Oshio, Koichi ; Grinspoon, Steven. / Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men : A 1H spectroscopic imaging study. In: Magnetic Resonance in Medicine. 2004 ; Vol. 52, No. 3. pp. 552-558.
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