Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection

Katsunori Masaki, Makoto Ishii, Masaki Anraku, Ho Namkoong, Ryo Miyakawa, Takeshi Nakajima, Koichi Fukunaga, Katsuhiko Naoki, Sadatomo Tasaka, Kenzo Soejima, Koichi Sayama, Kayoko Sugita, Satoshi Iwata, Longzhu Cui, Hideaki Hanaki, Naoki Hasegawa, Tomoko Betsuyaku

Research output: Contribution to journalArticle

Abstract

Objective: Rare disease Background: Increasing evidence has indicated that Staphylococcus aureus pneumonia complicated with influenza virus infection is often fatal. In these cases, disease severity is typically determined by susceptibility to antimicrobial agents and the presence of high-virulence factors that are produced by Staphylococcus aureus, such as Panton- Valentine leukocidin (PVL). Case Report: We describe a rare case of fatal community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus (MSSA), which did not secrete major high-virulence factors and coexisted with influenza type B infection. The 32-year-old previously healthy male patient presented with dyspnea, high fever, and cough. His roommate had been diagnosed with influenza B virus infection 3 days earlier. Gram-positive clusters of cocci were detected in the patient’s sputum; therefore, he was diagnosed with severe pneumonia and septic shock, and was admitted to the intensive care unit. Despite intensive antibiotic and antiviral treatment, he died of multiple organ failure 5 days after admission. His blood culture from the admission was positive for MSSA, and further analysis revealed that the strain was negative for major high-virulence factors, including PVL and enterotoxins, although influenza B virus RNA was detected by PCR. Conclusions: Physicians should pay special attention to patients with pneumonia following influenza and Staphylococcus aureus infection, as it may be fatal, even if the Staphylococcus aureus strain is PVL-negative and sensitive to antimicrobial agents.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalAmerican Journal of Case Reports
Volume16
DOIs
Publication statusPublished - 2015 Jul 14

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Influenza B virus
Methicillin
Virulence Factors
Virus Diseases
Staphylococcus aureus
Pneumonia
Anti-Infective Agents
Human Influenza
Staphylococcal Pneumonia
Gram-Positive Cocci
Multiple Organ Failure
Enterotoxins
Septic Shock
Rare Diseases
Infection
Orthomyxoviridae
Sputum
Cough
Dyspnea
Antiviral Agents

Keywords

  • Human
  • Influenza
  • Leukocidins
  • Pneumonia
  • Staphylococci

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection. / Masaki, Katsunori; Ishii, Makoto; Anraku, Masaki; Namkoong, Ho; Miyakawa, Ryo; Nakajima, Takeshi; Fukunaga, Koichi; Naoki, Katsuhiko; Tasaka, Sadatomo; Soejima, Kenzo; Sayama, Koichi; Sugita, Kayoko; Iwata, Satoshi; Cui, Longzhu; Hanaki, Hideaki; Hasegawa, Naoki; Betsuyaku, Tomoko.

In: American Journal of Case Reports, Vol. 16, 14.07.2015, p. 454-458.

Research output: Contribution to journalArticle

Masaki, Katsunori ; Ishii, Makoto ; Anraku, Masaki ; Namkoong, Ho ; Miyakawa, Ryo ; Nakajima, Takeshi ; Fukunaga, Koichi ; Naoki, Katsuhiko ; Tasaka, Sadatomo ; Soejima, Kenzo ; Sayama, Koichi ; Sugita, Kayoko ; Iwata, Satoshi ; Cui, Longzhu ; Hanaki, Hideaki ; Hasegawa, Naoki ; Betsuyaku, Tomoko. / Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection. In: American Journal of Case Reports. 2015 ; Vol. 16. pp. 454-458.
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AU - Ishii, Makoto

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AU - Namkoong, Ho

AU - Miyakawa, Ryo

AU - Nakajima, Takeshi

AU - Fukunaga, Koichi

AU - Naoki, Katsuhiko

AU - Tasaka, Sadatomo

AU - Soejima, Kenzo

AU - Sayama, Koichi

AU - Sugita, Kayoko

AU - Iwata, Satoshi

AU - Cui, Longzhu

AU - Hanaki, Hideaki

AU - Hasegawa, Naoki

AU - Betsuyaku, Tomoko

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