Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)

Y. Oshima, S. Takahashi, H. Nagayama, K. Nishiwaki, Y. Kobayashi, A. Tojo, Shinichiro Okamoto, K. Tani, K. Ozawa, T. Wakabayashi, N. Sato, S. Kobayashi, K. Nakamura, Y. Ohya, N. Nukina, I. Kanazawa, S. Asano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.

Original languageEnglish
Pages (from-to)737-740
Number of pages4
JournalBone Marrow Transplantation
Volume19
Issue number7
Publication statusPublished - 1997 Apr 1

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Leukocyte Transfusion
Respiratory Muscles
Tissue Donors
Siblings
Clone Cells
Bone Marrow
Cell Proliferation
Lymphocytes

Keywords

  • BMT
  • Donor leukocyte transfusion
  • GVHD
  • Myositis
  • Respiratory failure

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Oshima, Y., Takahashi, S., Nagayama, H., Nishiwaki, K., Kobayashi, Y., Tojo, A., ... Asano, S. (1997). Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow Transplantation, 19(7), 737-740.

Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). / Oshima, Y.; Takahashi, S.; Nagayama, H.; Nishiwaki, K.; Kobayashi, Y.; Tojo, A.; Okamoto, Shinichiro; Tani, K.; Ozawa, K.; Wakabayashi, T.; Sato, N.; Kobayashi, S.; Nakamura, K.; Ohya, Y.; Nukina, N.; Kanazawa, I.; Asano, S.

In: Bone Marrow Transplantation, Vol. 19, No. 7, 01.04.1997, p. 737-740.

Research output: Contribution to journalArticle

Oshima, Y, Takahashi, S, Nagayama, H, Nishiwaki, K, Kobayashi, Y, Tojo, A, Okamoto, S, Tani, K, Ozawa, K, Wakabayashi, T, Sato, N, Kobayashi, S, Nakamura, K, Ohya, Y, Nukina, N, Kanazawa, I & Asano, S 1997, 'Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)', Bone Marrow Transplantation, vol. 19, no. 7, pp. 737-740.
Oshima Y, Takahashi S, Nagayama H, Nishiwaki K, Kobayashi Y, Tojo A et al. Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow Transplantation. 1997 Apr 1;19(7):737-740.
Oshima, Y. ; Takahashi, S. ; Nagayama, H. ; Nishiwaki, K. ; Kobayashi, Y. ; Tojo, A. ; Okamoto, Shinichiro ; Tani, K. ; Ozawa, K. ; Wakabayashi, T. ; Sato, N. ; Kobayashi, S. ; Nakamura, K. ; Ohya, Y. ; Nukina, N. ; Kanazawa, I. ; Asano, S. / Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). In: Bone Marrow Transplantation. 1997 ; Vol. 19, No. 7. pp. 737-740.
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