Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient with Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride

Tadaki Nakahara; Yoshiki Owaki; Takeo Kosaka; Junichi Fukada; Akira Ichimura; Masahiro Jinzaki

doi:10.1097/RLU.0000000000002117

Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient with Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride

Tadaki Nakahara, Yoshiki Owaki, Takeo Kosaka, Junichi Fukada, Akira Ichimura, Masahiro Jinzaki

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A 64-year-old man with castration-resistant prostate cancer received ²²³Ra injection to treat bone metastases. The patient underwent a ²²³Ra SPECT scan after the first ²²³Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in ²²³Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm³). The extensive radiation to the spine may have enhanced myelophthisic process in this case.

Original language	English
Pages (from-to)	546-547
Number of pages	2
Journal	Clinical nuclear medicine
Volume	43
Issue number	7
DOIs	https://doi.org/10.1097/RLU.0000000000002117
Publication status	Published - 2018 Jul 1

Keywords

Ra
intracranial hemorrhage
myelotoxicity

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/RLU.0000000000002117

Cite this

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title = "Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient with Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride",

abstract = "A 64-year-old man with castration-resistant prostate cancer received 223Ra injection to treat bone metastases. The patient underwent a 223Ra SPECT scan after the first 223Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in 223Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm3). The extensive radiation to the spine may have enhanced myelophthisic process in this case.",

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T1 - Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient with Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride

AU - Nakahara, Tadaki

AU - Owaki, Yoshiki

AU - Kosaka, Takeo

AU - Fukada, Junichi

AU - Ichimura, Akira

AU - Jinzaki, Masahiro

PY - 2018/7/1

Y1 - 2018/7/1

N2 - A 64-year-old man with castration-resistant prostate cancer received 223Ra injection to treat bone metastases. The patient underwent a 223Ra SPECT scan after the first 223Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in 223Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm3). The extensive radiation to the spine may have enhanced myelophthisic process in this case.

AB - A 64-year-old man with castration-resistant prostate cancer received 223Ra injection to treat bone metastases. The patient underwent a 223Ra SPECT scan after the first 223Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in 223Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm3). The extensive radiation to the spine may have enhanced myelophthisic process in this case.

KW - Ra

KW - intracranial hemorrhage

KW - myelotoxicity

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Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient with Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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