Fatty liver quantification with line scan echo planar spectroscopic imaging (LSEPSI)

H. Shinmoto, Koichi Oshio, Y. Yuasa, Akihiro Tanimoto, Suketaka Momoshima, S. Kuribayashi, Hidetsugu Saito, Y. Imai, R. V. Mulkern

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Although fatty infiltration of liver is a benign process that generally results from chronic alcohol uptake or obesity, such lifestyle factors may lead to chronic disease. Measuring the fat concentration in liver may therefore prove useful in assessing disease status. In this study, we report the usefulness of line scan echo planar spectroscopic imaging (LSEPSI) for this problem. METHODS: Rapid successive column sampling was accomplished using orthogonal slice-selective 90 degrees and 180 degrees pulses and echo planar spectral/spatial encodings. Phantom and clinical studies of 13 patients suspected of having fatty liver were carried out with LSEPSI. Estimated fat fractions obtained with LSEPSI were compared with ultrasound findings. RESULTS: The results showed a good correlation between the actual fat content of phantoms and the estimated fat fraction obtained with LSEPSI (r = 0.95). In the clinical study, the estimated fat fraction tended to rise as the US grade of fatty liver increased. DISCUSSION: LSEPSI is largely free from T1 and T2 relaxation owing to its infinite TR and minimal T2 weighting. Thus, there is no need for relaxation analysis. In addition, the lack of phase encoding reduces motion-related ghosting artifacts. Rapid fat/water spectral quantification of liver with this technique is useful for fatty liver assessment in a clinical setting.

Original languageEnglish
Pages (from-to)715-720
Number of pages6
JournalNippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
Volume61
Issue number13
Publication statusPublished - 2001 Nov

Fingerprint

Echo-Planar Imaging
Fatty Liver
Fats
Liver
Artifacts
Life Style
Chronic Disease
Obesity
Alcohols
Water

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fatty liver quantification with line scan echo planar spectroscopic imaging (LSEPSI). / Shinmoto, H.; Oshio, Koichi; Yuasa, Y.; Tanimoto, Akihiro; Momoshima, Suketaka; Kuribayashi, S.; Saito, Hidetsugu; Imai, Y.; Mulkern, R. V.

In: Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, Vol. 61, No. 13, 11.2001, p. 715-720.

Research output: Contribution to journalArticle

@article{929e94a1da6546e288a1f214afa6c3e7,
title = "Fatty liver quantification with line scan echo planar spectroscopic imaging (LSEPSI)",
abstract = "INTRODUCTION: Although fatty infiltration of liver is a benign process that generally results from chronic alcohol uptake or obesity, such lifestyle factors may lead to chronic disease. Measuring the fat concentration in liver may therefore prove useful in assessing disease status. In this study, we report the usefulness of line scan echo planar spectroscopic imaging (LSEPSI) for this problem. METHODS: Rapid successive column sampling was accomplished using orthogonal slice-selective 90 degrees and 180 degrees pulses and echo planar spectral/spatial encodings. Phantom and clinical studies of 13 patients suspected of having fatty liver were carried out with LSEPSI. Estimated fat fractions obtained with LSEPSI were compared with ultrasound findings. RESULTS: The results showed a good correlation between the actual fat content of phantoms and the estimated fat fraction obtained with LSEPSI (r = 0.95). In the clinical study, the estimated fat fraction tended to rise as the US grade of fatty liver increased. DISCUSSION: LSEPSI is largely free from T1 and T2 relaxation owing to its infinite TR and minimal T2 weighting. Thus, there is no need for relaxation analysis. In addition, the lack of phase encoding reduces motion-related ghosting artifacts. Rapid fat/water spectral quantification of liver with this technique is useful for fatty liver assessment in a clinical setting.",
author = "H. Shinmoto and Koichi Oshio and Y. Yuasa and Akihiro Tanimoto and Suketaka Momoshima and S. Kuribayashi and Hidetsugu Saito and Y. Imai and Mulkern, {R. V.}",
year = "2001",
month = "11",
language = "English",
volume = "61",
pages = "715--720",
journal = "Nippon Acta Radiologica",
issn = "0048-0428",
publisher = "Japan Radiological Society",
number = "13",

}

TY - JOUR

T1 - Fatty liver quantification with line scan echo planar spectroscopic imaging (LSEPSI)

AU - Shinmoto, H.

AU - Oshio, Koichi

AU - Yuasa, Y.

AU - Tanimoto, Akihiro

AU - Momoshima, Suketaka

AU - Kuribayashi, S.

AU - Saito, Hidetsugu

AU - Imai, Y.

AU - Mulkern, R. V.

PY - 2001/11

Y1 - 2001/11

N2 - INTRODUCTION: Although fatty infiltration of liver is a benign process that generally results from chronic alcohol uptake or obesity, such lifestyle factors may lead to chronic disease. Measuring the fat concentration in liver may therefore prove useful in assessing disease status. In this study, we report the usefulness of line scan echo planar spectroscopic imaging (LSEPSI) for this problem. METHODS: Rapid successive column sampling was accomplished using orthogonal slice-selective 90 degrees and 180 degrees pulses and echo planar spectral/spatial encodings. Phantom and clinical studies of 13 patients suspected of having fatty liver were carried out with LSEPSI. Estimated fat fractions obtained with LSEPSI were compared with ultrasound findings. RESULTS: The results showed a good correlation between the actual fat content of phantoms and the estimated fat fraction obtained with LSEPSI (r = 0.95). In the clinical study, the estimated fat fraction tended to rise as the US grade of fatty liver increased. DISCUSSION: LSEPSI is largely free from T1 and T2 relaxation owing to its infinite TR and minimal T2 weighting. Thus, there is no need for relaxation analysis. In addition, the lack of phase encoding reduces motion-related ghosting artifacts. Rapid fat/water spectral quantification of liver with this technique is useful for fatty liver assessment in a clinical setting.

AB - INTRODUCTION: Although fatty infiltration of liver is a benign process that generally results from chronic alcohol uptake or obesity, such lifestyle factors may lead to chronic disease. Measuring the fat concentration in liver may therefore prove useful in assessing disease status. In this study, we report the usefulness of line scan echo planar spectroscopic imaging (LSEPSI) for this problem. METHODS: Rapid successive column sampling was accomplished using orthogonal slice-selective 90 degrees and 180 degrees pulses and echo planar spectral/spatial encodings. Phantom and clinical studies of 13 patients suspected of having fatty liver were carried out with LSEPSI. Estimated fat fractions obtained with LSEPSI were compared with ultrasound findings. RESULTS: The results showed a good correlation between the actual fat content of phantoms and the estimated fat fraction obtained with LSEPSI (r = 0.95). In the clinical study, the estimated fat fraction tended to rise as the US grade of fatty liver increased. DISCUSSION: LSEPSI is largely free from T1 and T2 relaxation owing to its infinite TR and minimal T2 weighting. Thus, there is no need for relaxation analysis. In addition, the lack of phase encoding reduces motion-related ghosting artifacts. Rapid fat/water spectral quantification of liver with this technique is useful for fatty liver assessment in a clinical setting.

UR - http://www.scopus.com/inward/record.url?scp=0035516246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035516246&partnerID=8YFLogxK

M3 - Article

C2 - 11766396

AN - SCOPUS:0035516246

VL - 61

SP - 715

EP - 720

JO - Nippon Acta Radiologica

JF - Nippon Acta Radiologica

SN - 0048-0428

IS - 13

ER -