Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma

S. Yano, T. Mori, Y. Kanda, J. Kato, C. Nakaseko, S. Fujisawa, N. Tomita, R. Sakai, K. Shono, T. Saitoh, N. Aotsuka, N. Kobayashi, T. Saito, S. Takahashi, H. Kanamori, S. Okamoto

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7 Citations (Scopus)

Abstract

Allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with relapsed follicular lymphoma (FL). Prospective studies of reduced-intensity conditioning (RIC) have revealed that chemosensitivity at allo-SCT is the most reliable predictor of outcome; however, limited data are available for progressive/refractory disease. We report here a retrospective analysis of RIC allo-SCT for patients with FL. The purpose of this study was to elucidate the role of allo-SCT for patients with relapsed/refractory FL. We analyzed 46 patients - 11 (24%) transplanted in CR, 6 (13%) transplanted in PR and 29 (63%) with progressive/refractory disease. The estimated 5-year overall survival rate was 71.6% (95% confidence interval (CI), 51.5-84.5%). According to the disease status at transplantation, the 5-year survival rate was 80.7% (95% CI, 37.7-95.4%) in the patients with CR or PR and 66.1% (95% CI, 41.5-82.3%) in those with progressive/refractory disease (P=0.29). There were no differences in relapse/progression and non-relapse mortality between the patients with chemosensitive disease and progressive/refractory disease. Allo-SCT may be a valuable treatment option, even for patients with progressive/refractory FL.

Original languageEnglish
Pages (from-to)1299-1305
Number of pages7
JournalBone Marrow Transplantation
Volume50
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Yano, S., Mori, T., Kanda, Y., Kato, J., Nakaseko, C., Fujisawa, S., Tomita, N., Sakai, R., Shono, K., Saitoh, T., Aotsuka, N., Kobayashi, N., Saito, T., Takahashi, S., Kanamori, H., & Okamoto, S. (2015). Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma. Bone Marrow Transplantation, 50(10), 1299-1305. https://doi.org/10.1038/bmt.2015.158