Feasibility and efficacy of combination chemotherapy with S-1 and fractional cisplatin for advanced gastric cancer

Tsunehiro Takahashi, Yoshiro Saikawa, Hiromasa Takaishi, Hiroya Takeuchi, Norihito Wada, Takashi Oyama, Rieko Nakamura, Yuko Kitagawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There is a great need for effective outpatient chemotherapy for advanced gastric cancer in patients with good performance status. The present pilot study evaluated the use of combination chemotherapy with S-1 and fractional CDDP for unresectable-recurrent gastric cancer in an outpatient setting. Patients and Methods: A total of 41 patients with unresectable or recurrent gastric cancer were treated with this combination chemotherapy. S-1 was administered orally every day on days 1-28 and CDDP was infused on days 1, 15, and 29. Results: Thirty-six patients had measurable lesions and 19 patients had partial responses, resulting in an overall response rate of 52.8%. The median survival time was 494 days. There was no grade 4 haematological toxicity, no grade 3 or more non-haematological toxicity, and no treatment-related death. Conclusion: This combination chemotherapy has no serious toxicities in patients with unresectable and recurrent gastric cancer and can be used effectively in an outpatient setting.

Original languageEnglish
Pages (from-to)3759-3762
Number of pages4
JournalAnticancer research
Volume30
Issue number9
Publication statusPublished - 2010 Sep

Keywords

  • Cisplatin
  • Gastric cancer
  • Outpatient setting
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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