Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

Tomoyoshi Tamura, Kei Hayashida, Motoaki Sano, Masaru Suzuki, Takayuki Shibusawa, Jo Yoshizawa, Yosuke Kobayashi, Takeshi Suzuki, Shigeo Ohta, Hiroshi Morisaki, Keiichi Fukuda, Shingo Hori

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

Original languageEnglish
Pages (from-to)1870-1873
Number of pages4
JournalCirculation Journal
Volume80
Issue number8
DOIs
Publication statusPublished - 2016

Fingerprint

Heart Arrest
Inhalation
Hydrogen
Gases
Safety
Out-of-Hospital Cardiac Arrest
Temperature
Animal Models

Keywords

  • Hydrogen gas inhalation
  • Molecular hydrogen
  • Post-cardiac arrest syndrome
  • Return of spontaneous circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study. / Tamura, Tomoyoshi; Hayashida, Kei; Sano, Motoaki; Suzuki, Masaru; Shibusawa, Takayuki; Yoshizawa, Jo; Kobayashi, Yosuke; Suzuki, Takeshi; Ohta, Shigeo; Morisaki, Hiroshi; Fukuda, Keiichi; Hori, Shingo.

In: Circulation Journal, Vol. 80, No. 8, 2016, p. 1870-1873.

Research output: Contribution to journalArticle

Tamura, Tomoyoshi ; Hayashida, Kei ; Sano, Motoaki ; Suzuki, Masaru ; Shibusawa, Takayuki ; Yoshizawa, Jo ; Kobayashi, Yosuke ; Suzuki, Takeshi ; Ohta, Shigeo ; Morisaki, Hiroshi ; Fukuda, Keiichi ; Hori, Shingo. / Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study. In: Circulation Journal. 2016 ; Vol. 80, No. 8. pp. 1870-1873.
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AU - Shibusawa, Takayuki

AU - Yoshizawa, Jo

AU - Kobayashi, Yosuke

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