Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome-first-in-human pilot study

Tomoyoshi Tamura, Kei Hayashida, Motoaki Sano, Masaru Suzuki, Takayuki Shibusawa, Jo Yoshizawa, Yosuke Kobayashi, Takeshi Suzuki, Shigeo Ohta, Hiroshi Morisaki, Keiichi Fukuda, Shingo Hori

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of postcardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied. Methods and Results: Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

Original languageEnglish
Pages (from-to)1870-1873
Number of pages4
JournalCirculation Journal
Volume80
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • Hydrogen gas inhalation
  • Molecular hydrogen
  • Post-cardiac arrest syndrome
  • Return of spontaneous circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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