Features and clinical implications of fasting intact proinsulin to insulin molar (P/I) ratio 2

Analysis on the correlation between P/I ratio and each factor in the type 2 diabetes mellitus

Shoji Kawazu, Masako Yazawa, Yasuo Imai, Hitoshi Horie, Yoshikazu Hisano, Yuhei Koyama, Hitoshi Ishida, Sachihiko Ozawa, Kiyoshi Suzuki, Yasuhiko Iwamoto, Hiroshi Sakura, Yasunori Kanazawa, Ryuzo Kawamori, Hiroshi Uchino, Tetsuro Kobayashi, Kaoru Aida, Shoichi Tomono, Shoichiro Nagasaka, Ikuro Matsuba, Taro Maruyama & 2 others Yoshifumi Saisho, Takeshi Kuzuya

Research output: Contribution to journalArticle

Abstract

We examined the characteristics of plasma intact proinsulin to insulin molar (P/I) ratio at fasting in the morning, using type 2 diabetic patients. P/I ratio showed a significant correlation with HOMA-β and Insulinogenic Index. In multivariate analysis, fasting plasma insulin was well associated with BMI, and intact proinsulin was associated with BMI and fasting plasma glucose. On the other hand, P/I ratio was associated with duration of diabetes in addition to the above. P/I ratio of the patients who were positive for family history showed significantly higher value than the non-family history group. Moreover, P/I ratio of the patients with diabetic complications showed significantly higher value than the non-complication group. Furthermore, P/I ratio of glibenclamide or glimepiride group, were significantly higher than that of the diet group. These results suggest that P/I ratio could be useful to understand pancreatic β cell dysfunction in type 2 diabetes mellitus, either for estimating the stage of diabetes or titrating the optimal drug therapy.

Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalJournal of the Japan Diabetes Society
Volume52
Issue number7
Publication statusPublished - 2009

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Proinsulin
Type 2 Diabetes Mellitus
Fasting
glimepiride
Insulin
Glyburide
Diabetes Complications
Multivariate Analysis
Diet
Glucose
Drug Therapy

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Features and clinical implications of fasting intact proinsulin to insulin molar (P/I) ratio 2 : Analysis on the correlation between P/I ratio and each factor in the type 2 diabetes mellitus. / Kawazu, Shoji; Yazawa, Masako; Imai, Yasuo; Horie, Hitoshi; Hisano, Yoshikazu; Koyama, Yuhei; Ishida, Hitoshi; Ozawa, Sachihiko; Suzuki, Kiyoshi; Iwamoto, Yasuhiko; Sakura, Hiroshi; Kanazawa, Yasunori; Kawamori, Ryuzo; Uchino, Hiroshi; Kobayashi, Tetsuro; Aida, Kaoru; Tomono, Shoichi; Nagasaka, Shoichiro; Matsuba, Ikuro; Maruyama, Taro; Saisho, Yoshifumi; Kuzuya, Takeshi.

In: Journal of the Japan Diabetes Society, Vol. 52, No. 7, 2009, p. 547-554.

Research output: Contribution to journalArticle

Kawazu, S, Yazawa, M, Imai, Y, Horie, H, Hisano, Y, Koyama, Y, Ishida, H, Ozawa, S, Suzuki, K, Iwamoto, Y, Sakura, H, Kanazawa, Y, Kawamori, R, Uchino, H, Kobayashi, T, Aida, K, Tomono, S, Nagasaka, S, Matsuba, I, Maruyama, T, Saisho, Y & Kuzuya, T 2009, 'Features and clinical implications of fasting intact proinsulin to insulin molar (P/I) ratio 2: Analysis on the correlation between P/I ratio and each factor in the type 2 diabetes mellitus', Journal of the Japan Diabetes Society, vol. 52, no. 7, pp. 547-554.
Kawazu, Shoji ; Yazawa, Masako ; Imai, Yasuo ; Horie, Hitoshi ; Hisano, Yoshikazu ; Koyama, Yuhei ; Ishida, Hitoshi ; Ozawa, Sachihiko ; Suzuki, Kiyoshi ; Iwamoto, Yasuhiko ; Sakura, Hiroshi ; Kanazawa, Yasunori ; Kawamori, Ryuzo ; Uchino, Hiroshi ; Kobayashi, Tetsuro ; Aida, Kaoru ; Tomono, Shoichi ; Nagasaka, Shoichiro ; Matsuba, Ikuro ; Maruyama, Taro ; Saisho, Yoshifumi ; Kuzuya, Takeshi. / Features and clinical implications of fasting intact proinsulin to insulin molar (P/I) ratio 2 : Analysis on the correlation between P/I ratio and each factor in the type 2 diabetes mellitus. In: Journal of the Japan Diabetes Society. 2009 ; Vol. 52, No. 7. pp. 547-554.
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abstract = "We examined the characteristics of plasma intact proinsulin to insulin molar (P/I) ratio at fasting in the morning, using type 2 diabetic patients. P/I ratio showed a significant correlation with HOMA-β and Insulinogenic Index. In multivariate analysis, fasting plasma insulin was well associated with BMI, and intact proinsulin was associated with BMI and fasting plasma glucose. On the other hand, P/I ratio was associated with duration of diabetes in addition to the above. P/I ratio of the patients who were positive for family history showed significantly higher value than the non-family history group. Moreover, P/I ratio of the patients with diabetic complications showed significantly higher value than the non-complication group. Furthermore, P/I ratio of glibenclamide or glimepiride group, were significantly higher than that of the diet group. These results suggest that P/I ratio could be useful to understand pancreatic β cell dysfunction in type 2 diabetes mellitus, either for estimating the stage of diabetes or titrating the optimal drug therapy.",
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T1 - Features and clinical implications of fasting intact proinsulin to insulin molar (P/I) ratio 2

T2 - Analysis on the correlation between P/I ratio and each factor in the type 2 diabetes mellitus

AU - Kawazu, Shoji

AU - Yazawa, Masako

AU - Imai, Yasuo

AU - Horie, Hitoshi

AU - Hisano, Yoshikazu

AU - Koyama, Yuhei

AU - Ishida, Hitoshi

AU - Ozawa, Sachihiko

AU - Suzuki, Kiyoshi

AU - Iwamoto, Yasuhiko

AU - Sakura, Hiroshi

AU - Kanazawa, Yasunori

AU - Kawamori, Ryuzo

AU - Uchino, Hiroshi

AU - Kobayashi, Tetsuro

AU - Aida, Kaoru

AU - Tomono, Shoichi

AU - Nagasaka, Shoichiro

AU - Matsuba, Ikuro

AU - Maruyama, Taro

AU - Saisho, Yoshifumi

AU - Kuzuya, Takeshi

PY - 2009

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