Female-specific intergenerational transmission patterns of the human corticolimbic circuitry

Bun Yamagata, Kou Murayama, Jessica M. Black, Roeland Hancock, Masaru Mimura, Tony T. Yang, Allan L. Reiss, Fumiko Hoeft

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Parents have large genetic and environmental influences on offspring’s cognition, behavior, and brain. These intergenerational effects are observed in mood disorders, with particularly robust association in depression between mothers and daughters. No studies have thus far examined the neural bases of these intergenerational effects in humans. Corticolimbic circuitry isknownto be highly relevant in a wide range of processes, including mood regulation and depression. These findings suggest that corticolimbic circuitry may also show matrilineal transmission patterns. Therefore, we examined human parent– offspring association in this neurocircuitry and investigated the degree of association in gray matter volume between parent and offspring. We used voxelwise correlation analysis in a total of 35 healthy families, consisting of parents and their biological offspring. We found positive associations of regional gray matter volume in the corticolimbic circuit, including the amygdala, hippocampus, anterior cingulate cortex, and ventromedial prefrontal cortex between biological mothers and daughters. This association was significantly greater than mother–son, father– daughter, and father–son associations. The current study suggests that the corticolimbic circuitry, which has been implicated in mood regulation, shows a matrilinealspecific transmission patterns. Our preliminary findings are consistent with what has been found behaviorally in depression and may have clinical implications for disorders known to have dysfunction in mood regulation such as depression. Studies such as ours will likely bridge animal work examining gene expression in the brains and clinical symptom-based observations and provide promising ways to investigate intergenerational transmission patterns in the human brain.

Original languageEnglish
Pages (from-to)1254-1260
Number of pages7
JournalJournal of Neuroscience
Volume36
Issue number4
DOIs
Publication statusPublished - 2016 Jan 27

Fingerprint

Nuclear Family
Depression
Brain
Parents
Mothers
Gyrus Cinguli
Amygdala
Prefrontal Cortex
Mood Disorders
Fathers
Cognition
Hippocampus
Gene Expression
Gray Matter

Keywords

  • Anxiety disorder
  • Intergenerational imaging
  • MRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Female-specific intergenerational transmission patterns of the human corticolimbic circuitry. / Yamagata, Bun; Murayama, Kou; Black, Jessica M.; Hancock, Roeland; Mimura, Masaru; Yang, Tony T.; Reiss, Allan L.; Hoeft, Fumiko.

In: Journal of Neuroscience, Vol. 36, No. 4, 27.01.2016, p. 1254-1260.

Research output: Contribution to journalArticle

Yamagata, Bun ; Murayama, Kou ; Black, Jessica M. ; Hancock, Roeland ; Mimura, Masaru ; Yang, Tony T. ; Reiss, Allan L. ; Hoeft, Fumiko. / Female-specific intergenerational transmission patterns of the human corticolimbic circuitry. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 4. pp. 1254-1260.
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