Feminizing adrenocortical carcinoma with distinct histopathological findings

Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

Original languageEnglish
Pages (from-to)3301-3307
Number of pages7
JournalInternal Medicine
Volume55
Issue number22
DOIs
Publication statusPublished - 2016

Fingerprint

Adrenocortical Carcinoma
Adosterol
Gynecomastia
Dehydroepiandrosterone Sulfate
Aromatase
Glandular and Epithelial Neoplasms
Adrenalectomy
Radionuclide Imaging
Iodine
Testosterone
Magnetic Resonance Imaging
Polymerase Chain Reaction
Serum
Neoplasms

Keywords

  • Adrenocortical carcinoma
  • Aromatase
  • Estrogen-producing tumor
  • Gynecomastia
  • Testosterone

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hatano, M., Takenaka, Y., Inoue, I., Homma, K., Hasegawa, T., Sasano, H., ... Katayama, S. (2016). Feminizing adrenocortical carcinoma with distinct histopathological findings. Internal Medicine, 55(22), 3301-3307. https://doi.org/10.2169/internalmedicine.55.5912

Feminizing adrenocortical carcinoma with distinct histopathological findings. / Hatano, Masako; Takenaka, Yasuhiro; Inoue, Ikuo; Homma, Keiko; Hasegawa, Tomonobu; Sasano, Hisanobu; Awata, Takuya; Katayama, Shigehiro.

In: Internal Medicine, Vol. 55, No. 22, 2016, p. 3301-3307.

Research output: Contribution to journalArticle

Hatano, M, Takenaka, Y, Inoue, I, Homma, K, Hasegawa, T, Sasano, H, Awata, T & Katayama, S 2016, 'Feminizing adrenocortical carcinoma with distinct histopathological findings', Internal Medicine, vol. 55, no. 22, pp. 3301-3307. https://doi.org/10.2169/internalmedicine.55.5912
Hatano, Masako ; Takenaka, Yasuhiro ; Inoue, Ikuo ; Homma, Keiko ; Hasegawa, Tomonobu ; Sasano, Hisanobu ; Awata, Takuya ; Katayama, Shigehiro. / Feminizing adrenocortical carcinoma with distinct histopathological findings. In: Internal Medicine. 2016 ; Vol. 55, No. 22. pp. 3301-3307.
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