Feminizing adrenocortical carcinoma with distinct histopathological findings

Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama

Research output: Contribution to journalArticle

1 Citation (Scopus)


We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

Original languageEnglish
Pages (from-to)3301-3307
Number of pages7
JournalInternal Medicine
Issue number22
Publication statusPublished - 2016


  • Adrenocortical carcinoma
  • Aromatase
  • Estrogen-producing tumor
  • Gynecomastia
  • Testosterone

ASJC Scopus subject areas

  • Internal Medicine

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    Hatano, M., Takenaka, Y., Inoue, I., Homma, K., Hasegawa, T., Sasano, H., Awata, T., & Katayama, S. (2016). Feminizing adrenocortical carcinoma with distinct histopathological findings. Internal Medicine, 55(22), 3301-3307. https://doi.org/10.2169/internalmedicine.55.5912