Femtoliter-droplet shooting by micro/nano fluidics for digital mass spectrometry

Yuto Takagi, Yutaka Kazoe, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We designed and fabricated micro/nano droplet shooter devices that achieved 700 fL droplet shooting at 24 kHz exploiting laminar air flows for realizing 100% sample injection into mass spectrometry. It is a novel concept of digitizing a chromatograph by shooting sample droplets. The generated droplet diameter and the sample channel size were found to be in a linear relationship. Therefore, by further miniaturizing the shooter, the droplet miniaturization will be realized. This study will provide a great foothold for establishing single cell protein separation analysis which is important in biology and medicine.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages947-948
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Externally publishedYes
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 2019 Oct 272019 Oct 31

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period19/10/2719/10/31

Keywords

  • Droplet
  • Mass spectrometry
  • Microfluidics
  • Nanofluidics

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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