Femtosecond laser irradiation of the fluorescent molecules-loaded poly(lactic-co-glycolic acid)

Taiga Umemoto, Akimichi Shibata, Mitsuhiro Terakawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Molecular release from scaffolds is desired for tailoring cell-compatible tissue engineering. Several methods have been proposed to control molecular release, such as annealing, plasma treatment, and laser processing. In this study, we describe the alteration of Rhodamine B (RhB)-loaded poly(lactic-co-glycolic acid) (PLGA) after femtosecond laser irradiation, which was evaluated on the basis of the water absorption and mass remaining. Fluorescence measurement of released RhB molecules revealed the acceleration of the molecular release upon 400-nm laser irradiation, whereas 800-nm laser irradiation did not induce a comparable degree of change compared with non-irradiated samples. The result of the water absorption measurement indicates that the large amount of water absorption of 400-nm laser-irradiated PLGA sample may accelerate the diffusion of the loaded molecules through absorbing water, which resulted in the faster molecular release.

Original languageEnglish
JournalApplied Surface Science
DOIs
Publication statusAccepted/In press - 2016 Oct 28

Fingerprint

rhodamine B
Water absorption
Laser beam effects
Ultrashort pulses
Molecules
Acids
Lasers
Scaffolds (biology)
Tissue engineering
Fluorescence
Annealing
Plasmas
Water
Processing
polylactic acid-polyglycolic acid copolymer
Milk

Keywords

  • Biodegradable polymer
  • Controlled release
  • Degradation
  • Femtosecond laser

ASJC Scopus subject areas

  • Surfaces, Coatings and Films

Cite this

Femtosecond laser irradiation of the fluorescent molecules-loaded poly(lactic-co-glycolic acid). / Umemoto, Taiga; Shibata, Akimichi; Terakawa, Mitsuhiro.

In: Applied Surface Science, 28.10.2016.

Research output: Contribution to journalArticle

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