Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

T. Umemoto, Mitsuhiro Terakawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

    Original languageEnglish
    Title of host publicationFrontiers in Ultrafast Optics
    Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVIII
    EditorsPeter R. Herman, Michel Meunier, Roberto Osellame
    PublisherSPIE
    Volume10522
    ISBN (Electronic)9781510615298
    DOIs
    Publication statusPublished - 2018 Jan 1
    EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018 - San Francisco, United States
    Duration: 2018 Jan 282018 Jan 30

    Other

    OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018
    CountryUnited States
    CitySan Francisco
    Period18/1/2818/1/30

    Keywords

    • Biodegradable polymer microcapsules
    • Controlled release
    • Femtosecond laser
    • PLGA

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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  • Cite this

    Umemoto, T., & Terakawa, M. (2018). Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. In P. R. Herman, M. Meunier, & R. Osellame (Eds.), Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII (Vol. 10522). [1052203] SPIE. https://doi.org/10.1117/12.2287651