Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

T. Umemoto, Mitsuhiro Terakawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

Original languageEnglish
Title of host publicationFrontiers in Ultrafast Optics
Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVIII
EditorsPeter R. Herman, Michel Meunier, Roberto Osellame
PublisherSPIE
Volume10522
ISBN (Electronic)9781510615298
DOIs
Publication statusPublished - 2018 Jan 1
EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018 - San Francisco, United States
Duration: 2018 Jan 282018 Jan 30

Other

OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018
CountryUnited States
CitySan Francisco
Period18/1/2818/1/30

Fingerprint

Hydrogel
Biodegradable polymers
Femtosecond Laser
gelatins
Gelatin
Ultrashort pulses
Hydrogels
Capsules
Polymers
Tissue Engineering
tissue engineering
polymers
Tissue engineering
lasers
coaxial nozzles
Molecules
Laser
Tissue Scaffolds
Femtosecond Laser Pulses
Lasers

Keywords

  • Biodegradable polymer microcapsules
  • Controlled release
  • Femtosecond laser
  • PLGA

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Umemoto, T., & Terakawa, M. (2018). Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. In P. R. Herman, M. Meunier, & R. Osellame (Eds.), Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII (Vol. 10522). [1052203] SPIE. https://doi.org/10.1117/12.2287651

Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. / Umemoto, T.; Terakawa, Mitsuhiro.

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII. ed. / Peter R. Herman; Michel Meunier; Roberto Osellame. Vol. 10522 SPIE, 2018. 1052203.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Umemoto, T & Terakawa, M 2018, Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. in PR Herman, M Meunier & R Osellame (eds), Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII. vol. 10522, 1052203, SPIE, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018, San Francisco, United States, 18/1/28. https://doi.org/10.1117/12.2287651
Umemoto T, Terakawa M. Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. In Herman PR, Meunier M, Osellame R, editors, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII. Vol. 10522. SPIE. 2018. 1052203 https://doi.org/10.1117/12.2287651
Umemoto, T. ; Terakawa, Mitsuhiro. / Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel. Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII. editor / Peter R. Herman ; Michel Meunier ; Roberto Osellame. Vol. 10522 SPIE, 2018.
@inproceedings{88bed4b2683248f58708ca8a8984bbd8,
title = "Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel",
abstract = "Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.",
keywords = "Biodegradable polymer microcapsules, Controlled release, Femtosecond laser, PLGA",
author = "T. Umemoto and Mitsuhiro Terakawa",
year = "2018",
month = "1",
day = "1",
doi = "10.1117/12.2287651",
language = "English",
volume = "10522",
editor = "Herman, {Peter R.} and Michel Meunier and Roberto Osellame",
booktitle = "Frontiers in Ultrafast Optics",
publisher = "SPIE",

}

TY - GEN

T1 - Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

AU - Umemoto, T.

AU - Terakawa, Mitsuhiro

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

AB - Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

KW - Biodegradable polymer microcapsules

KW - Controlled release

KW - Femtosecond laser

KW - PLGA

UR - http://www.scopus.com/inward/record.url?scp=85048535003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048535003&partnerID=8YFLogxK

U2 - 10.1117/12.2287651

DO - 10.1117/12.2287651

M3 - Conference contribution

AN - SCOPUS:85048535003

VL - 10522

BT - Frontiers in Ultrafast Optics

A2 - Herman, Peter R.

A2 - Meunier, Michel

A2 - Osellame, Roberto

PB - SPIE

ER -