Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

T. Umemoto, M. Terakawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

Original languageEnglish
Title of host publicationFrontiers in Ultrafast Optics
Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVIII
EditorsPeter R. Herman, Michel Meunier, Roberto Osellame
PublisherSPIE
ISBN (Electronic)9781510615298
DOIs
Publication statusPublished - 2018
EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018 - San Francisco, United States
Duration: 2018 Jan 282018 Jan 30

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10522
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII 2018
CountryUnited States
CitySan Francisco
Period18/1/2818/1/30

Keywords

  • Biodegradable polymer microcapsules
  • Controlled release
  • Femtosecond laser
  • PLGA

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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