Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report

Tadashi Matsumoto; Kei Miyakoshi; Kenji Kasai; Hitoshi Ishimoto; Mamoru Tanaka; Kazushige Ikeda; Yasunori Yoshimura

doi:10.1159/000073143

Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report

Tadashi Matsumoto, Kei Miyakoshi, Kenji Kasai, Hitoshi Ishimoto, Mamoru Tanaka, Kazushige Ikeda, Yasunori Yoshimura

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.

Original language	English
Pages (from-to)	459-462
Number of pages	4
Journal	Fetal Diagnosis and Therapy
Volume	18
Issue number	6
DOIs	https://doi.org/10.1159/000073143
Publication status	Published - 2003 Nov 7

Keywords

Fetal goiter
Intrauterine treatment
Thyroid dysfunction

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Embryology
Radiology Nuclear Medicine and imaging
Obstetrics and Gynaecology

Access to Document

10.1159/000073143

Fingerprint Dive into the research topics of 'Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report'. Together they form a unique fingerprint.

Cite this

@article{078f5930190c4504a5daec878ee110ec,

title = "Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report",

abstract = "We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.",

keywords = "Fetal goiter, Intrauterine treatment, Thyroid dysfunction",

author = "Tadashi Matsumoto and Kei Miyakoshi and Kenji Kasai and Hitoshi Ishimoto and Mamoru Tanaka and Kazushige Ikeda and Yasunori Yoshimura",

year = "2003",

month = nov,

day = "7",

doi = "10.1159/000073143",

language = "English",

volume = "18",

pages = "459--462",

journal = "Fetal Diagnosis and Therapy",

issn = "1015-3837",

publisher = "S. Karger AG",

number = "6",

}

TY - JOUR

T1 - Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism

T2 - A case report

AU - Matsumoto, Tadashi

AU - Miyakoshi, Kei

AU - Kasai, Kenji

AU - Ishimoto, Hitoshi

AU - Tanaka, Mamoru

AU - Ikeda, Kazushige

AU - Yoshimura, Yasunori

PY - 2003/11/7

Y1 - 2003/11/7

N2 - We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.

AB - We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.

KW - Fetal goiter

KW - Intrauterine treatment

KW - Thyroid dysfunction

UR - http://www.scopus.com/inward/record.url?scp=0142258889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142258889&partnerID=8YFLogxK

U2 - 10.1159/000073143

DO - 10.1159/000073143

M3 - Article

C2 - 14564120

AN - SCOPUS:0142258889

VL - 18

SP - 459

EP - 462

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

SN - 1015-3837

IS - 6

ER -