FGF-2 stimulates periodontal regeneration: Results of a multi-center randomized clinical trial

M. Kitamura, M. Akamatsu, M. MacHigashira, Y. Hara, R. Sakagami, T. Hirofuji, T. Hamachi, K. Maeda, M. Yokota, J. Kido, T. Nagata, H. Kurihara, S. Takashiba, T. Sibutani, M. Fukuda, T. Noguchi, K. Yamazaki, H. Yoshie, K. Ioroi, T. AraiT. Nakagawa, K. Ito, S. Oda, Y. Izumi, Y. Ogata, S. Yamada, H. Shimauchi, K. Kunimatsu, M. Kawanami, T. Fujii, Y. Furuichi, T. Furuuchi, T. Sasano, E. Imai, M. Omae, S. Yamada, M. Watanuki, S. Murakami

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126 Citations (Scopus)

Abstract

The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 μL of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Dental Research
Volume90
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Keywords

  • fibroblast growth factor-2
  • periodontitis
  • tissue regeneration

ASJC Scopus subject areas

  • Dentistry(all)

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    Kitamura, M., Akamatsu, M., MacHigashira, M., Hara, Y., Sakagami, R., Hirofuji, T., Hamachi, T., Maeda, K., Yokota, M., Kido, J., Nagata, T., Kurihara, H., Takashiba, S., Sibutani, T., Fukuda, M., Noguchi, T., Yamazaki, K., Yoshie, H., Ioroi, K., ... Murakami, S. (2011). FGF-2 stimulates periodontal regeneration: Results of a multi-center randomized clinical trial. Journal of Dental Research, 90(1), 35-40. https://doi.org/10.1177/0022034510384616