Fgf/MAPK signalling is a crucial positional cue in somite boundary formation

A. Sawada, Minori Shinya, Y. J. Jiang, A. Kawakami, A. Kuroiwa, H. Takeda

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.

Original languageEnglish
Pages (from-to)4873-4880
Number of pages8
JournalDevelopment
Volume128
Issue number23
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Somites
Mesoderm
Cues
Zebrafish
Genes

Keywords

  • After eight
  • Fgf
  • Fused somites
  • Her1
  • Segmentation
  • Somite
  • Tailbud
  • Zebrafish

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Sawada, A., Shinya, M., Jiang, Y. J., Kawakami, A., Kuroiwa, A., & Takeda, H. (2001). Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development, 128(23), 4873-4880.

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. / Sawada, A.; Shinya, Minori; Jiang, Y. J.; Kawakami, A.; Kuroiwa, A.; Takeda, H.

In: Development, Vol. 128, No. 23, 2001, p. 4873-4880.

Research output: Contribution to journalArticle

Sawada, A, Shinya, M, Jiang, YJ, Kawakami, A, Kuroiwa, A & Takeda, H 2001, 'Fgf/MAPK signalling is a crucial positional cue in somite boundary formation', Development, vol. 128, no. 23, pp. 4873-4880.
Sawada A, Shinya M, Jiang YJ, Kawakami A, Kuroiwa A, Takeda H. Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development. 2001;128(23):4873-4880.
Sawada, A. ; Shinya, Minori ; Jiang, Y. J. ; Kawakami, A. ; Kuroiwa, A. ; Takeda, H. / Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. In: Development. 2001 ; Vol. 128, No. 23. pp. 4873-4880.
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