Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstruction

Ryo Sato; Hiroaki Onoe

doi:10.1109/MEMSYS.2017.7863387

Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstruction

Ryo Sato, Hiroaki Onoe

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

This paper describes a fiber-shaped microscale tissue with blood vessel networks. We co-cultured Hep-G2 (Human hepatic epithelial cell line) and HUVEC (human umbilical endothelial cell) in a collagen/alginate core-shell hydrogel microfiber fabricated by using a microfluidic device. We observed difference in construction of blood vessel networks in the hepatic tissue by varying in the ratio of co-cultured cells and the diameter of the core. In addition, by arranging the fiber-shaped tissues to construct macroscale tissue assembly, we confirmed the connection of blood vessel networks between the assembled fiber-shaped tissues.

Original language	English
Title of host publication	2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	247-250
Number of pages	4
ISBN (Electronic)	9781509050789
DOIs	https://doi.org/10.1109/MEMSYS.2017.7863387
Publication status	Published - 2017 Feb 23
Event	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States Duration: 2017 Jan 22 → 2017 Jan 26

Other

Other	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
Country/Territory	United States
City	Las Vegas
Period	17/1/22 → 17/1/26

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

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10.1109/MEMSYS.2017.7863387

Cite this

Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstruction. / Sato, Ryo; Onoe, Hiroaki.

2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 247-250 7863387.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sato, R & Onoe, H 2017, Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstruction. in 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017., 7863387, Institute of Electrical and Electronics Engineers Inc., pp. 247-250, 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017, Las Vegas, United States, 17/1/22. https://doi.org/10.1109/MEMSYS.2017.7863387

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abstract = "This paper describes a fiber-shaped microscale tissue with blood vessel networks. We co-cultured Hep-G2 (Human hepatic epithelial cell line) and HUVEC (human umbilical endothelial cell) in a collagen/alginate core-shell hydrogel microfiber fabricated by using a microfluidic device. We observed difference in construction of blood vessel networks in the hepatic tissue by varying in the ratio of co-cultured cells and the diameter of the core. In addition, by arranging the fiber-shaped tissues to construct macroscale tissue assembly, we confirmed the connection of blood vessel networks between the assembled fiber-shaped tissues.",

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AB - This paper describes a fiber-shaped microscale tissue with blood vessel networks. We co-cultured Hep-G2 (Human hepatic epithelial cell line) and HUVEC (human umbilical endothelial cell) in a collagen/alginate core-shell hydrogel microfiber fabricated by using a microfluidic device. We observed difference in construction of blood vessel networks in the hepatic tissue by varying in the ratio of co-cultured cells and the diameter of the core. In addition, by arranging the fiber-shaped tissues to construct macroscale tissue assembly, we confirmed the connection of blood vessel networks between the assembled fiber-shaped tissues.

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Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstruction

Abstract

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