Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma: Clinicopathologic study of 152 first resection cases

Keiichi Okano, Junji Yamamoto, Tomoo Kosuge, Seiichiro Yamamoto, Michiie Sakamoto, Yukihiro Nakanishi, Setsuo Hirohashi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

BACKGROUND. The presence of pseudocapsules of liver tumors has been recognized in hepatocellular carcinoma and is known to be a favorable prognostic factor. Although several studies have reported pseudocapsules around metastatic liver tumors, to the authors' knowledge there have been few evaluations of the clinical significance of such features in patients with metastatic colorectal carcinoma. METHODS. A clinicopathologic study was conducted in 152 patients who underwent initial hepatic resection for metastatic colorectal carcinoma. RESULTS. The presence of fibrous tissue between the tumor and the surrounding hepatic parenchyma was noted in 93 of the 152 patients (61%) with colorectal liver metastases. These patients were classified as having a thin pseudocapsule (n = 46) or a thick pseudocapsule (n = 47), according to the number of collagen bundles (< 10 or ≥ 10) between the tumor and the hepatic parenchyma in histologic sections. Pathologically, the presence and thickness of the fibrous pseudocapsule were related closely to less invasiveness into adjacent vessels (P = 0.004) and the presence of macroscopic intrabile ductal invasion (P = 0.008). The postresection survival was significantly better in patients with thick or thin pseudocapsules than in those without a pseudocapsule (3-year and 5- year cumulative survival rates of patients with no, thin, and thick pseudocapsules were 41% and 31%, respectively, 71% and 64%, respectively, and 88% and 88%, respectively; P < 0.001). In a multivariate analysis using the Cox proportional hazards model, after adjusting for other potential prognostic factors (vascular invasion, bile ductal invasion, number of tumors, tumor size, and curativeness of surgery), the presence of a fibrous pseudocapsule was an independent predictor of a favorable outcome after hepatic resection. CONCLUSIONS. The presence of fibrous tissue between the tumor and the liver parenchyma was a promising indicator of a better prognosis after resection in patients with colorectal liver metastases. (C) 2000 American Cancer Society.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalCancer
Volume89
Issue number2
DOIs
Publication statusPublished - 2000 Jul 15
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Liver
Neoplasms
Neoplasm Metastasis
Proportional Hazards Models
Bile
Blood Vessels
Hepatocellular Carcinoma
Collagen
Multivariate Analysis
Survival Rate
Survival

Keywords

  • Colorectal carcinoma
  • Fibrous pseudocapsule
  • Hepatic resection
  • Liver metastases
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma : Clinicopathologic study of 152 first resection cases. / Okano, Keiichi; Yamamoto, Junji; Kosuge, Tomoo; Yamamoto, Seiichiro; Sakamoto, Michiie; Nakanishi, Yukihiro; Hirohashi, Setsuo.

In: Cancer, Vol. 89, No. 2, 15.07.2000, p. 267-275.

Research output: Contribution to journalArticle

Okano, Keiichi ; Yamamoto, Junji ; Kosuge, Tomoo ; Yamamoto, Seiichiro ; Sakamoto, Michiie ; Nakanishi, Yukihiro ; Hirohashi, Setsuo. / Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma : Clinicopathologic study of 152 first resection cases. In: Cancer. 2000 ; Vol. 89, No. 2. pp. 267-275.
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abstract = "BACKGROUND. The presence of pseudocapsules of liver tumors has been recognized in hepatocellular carcinoma and is known to be a favorable prognostic factor. Although several studies have reported pseudocapsules around metastatic liver tumors, to the authors' knowledge there have been few evaluations of the clinical significance of such features in patients with metastatic colorectal carcinoma. METHODS. A clinicopathologic study was conducted in 152 patients who underwent initial hepatic resection for metastatic colorectal carcinoma. RESULTS. The presence of fibrous tissue between the tumor and the surrounding hepatic parenchyma was noted in 93 of the 152 patients (61{\%}) with colorectal liver metastases. These patients were classified as having a thin pseudocapsule (n = 46) or a thick pseudocapsule (n = 47), according to the number of collagen bundles (< 10 or ≥ 10) between the tumor and the hepatic parenchyma in histologic sections. Pathologically, the presence and thickness of the fibrous pseudocapsule were related closely to less invasiveness into adjacent vessels (P = 0.004) and the presence of macroscopic intrabile ductal invasion (P = 0.008). The postresection survival was significantly better in patients with thick or thin pseudocapsules than in those without a pseudocapsule (3-year and 5- year cumulative survival rates of patients with no, thin, and thick pseudocapsules were 41{\%} and 31{\%}, respectively, 71{\%} and 64{\%}, respectively, and 88{\%} and 88{\%}, respectively; P < 0.001). In a multivariate analysis using the Cox proportional hazards model, after adjusting for other potential prognostic factors (vascular invasion, bile ductal invasion, number of tumors, tumor size, and curativeness of surgery), the presence of a fibrous pseudocapsule was an independent predictor of a favorable outcome after hepatic resection. CONCLUSIONS. The presence of fibrous tissue between the tumor and the liver parenchyma was a promising indicator of a better prognosis after resection in patients with colorectal liver metastases. (C) 2000 American Cancer Society.",
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T1 - Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma

T2 - Clinicopathologic study of 152 first resection cases

AU - Okano, Keiichi

AU - Yamamoto, Junji

AU - Kosuge, Tomoo

AU - Yamamoto, Seiichiro

AU - Sakamoto, Michiie

AU - Nakanishi, Yukihiro

AU - Hirohashi, Setsuo

PY - 2000/7/15

Y1 - 2000/7/15

N2 - BACKGROUND. The presence of pseudocapsules of liver tumors has been recognized in hepatocellular carcinoma and is known to be a favorable prognostic factor. Although several studies have reported pseudocapsules around metastatic liver tumors, to the authors' knowledge there have been few evaluations of the clinical significance of such features in patients with metastatic colorectal carcinoma. METHODS. A clinicopathologic study was conducted in 152 patients who underwent initial hepatic resection for metastatic colorectal carcinoma. RESULTS. The presence of fibrous tissue between the tumor and the surrounding hepatic parenchyma was noted in 93 of the 152 patients (61%) with colorectal liver metastases. These patients were classified as having a thin pseudocapsule (n = 46) or a thick pseudocapsule (n = 47), according to the number of collagen bundles (< 10 or ≥ 10) between the tumor and the hepatic parenchyma in histologic sections. Pathologically, the presence and thickness of the fibrous pseudocapsule were related closely to less invasiveness into adjacent vessels (P = 0.004) and the presence of macroscopic intrabile ductal invasion (P = 0.008). The postresection survival was significantly better in patients with thick or thin pseudocapsules than in those without a pseudocapsule (3-year and 5- year cumulative survival rates of patients with no, thin, and thick pseudocapsules were 41% and 31%, respectively, 71% and 64%, respectively, and 88% and 88%, respectively; P < 0.001). In a multivariate analysis using the Cox proportional hazards model, after adjusting for other potential prognostic factors (vascular invasion, bile ductal invasion, number of tumors, tumor size, and curativeness of surgery), the presence of a fibrous pseudocapsule was an independent predictor of a favorable outcome after hepatic resection. CONCLUSIONS. The presence of fibrous tissue between the tumor and the liver parenchyma was a promising indicator of a better prognosis after resection in patients with colorectal liver metastases. (C) 2000 American Cancer Society.

AB - BACKGROUND. The presence of pseudocapsules of liver tumors has been recognized in hepatocellular carcinoma and is known to be a favorable prognostic factor. Although several studies have reported pseudocapsules around metastatic liver tumors, to the authors' knowledge there have been few evaluations of the clinical significance of such features in patients with metastatic colorectal carcinoma. METHODS. A clinicopathologic study was conducted in 152 patients who underwent initial hepatic resection for metastatic colorectal carcinoma. RESULTS. The presence of fibrous tissue between the tumor and the surrounding hepatic parenchyma was noted in 93 of the 152 patients (61%) with colorectal liver metastases. These patients were classified as having a thin pseudocapsule (n = 46) or a thick pseudocapsule (n = 47), according to the number of collagen bundles (< 10 or ≥ 10) between the tumor and the hepatic parenchyma in histologic sections. Pathologically, the presence and thickness of the fibrous pseudocapsule were related closely to less invasiveness into adjacent vessels (P = 0.004) and the presence of macroscopic intrabile ductal invasion (P = 0.008). The postresection survival was significantly better in patients with thick or thin pseudocapsules than in those without a pseudocapsule (3-year and 5- year cumulative survival rates of patients with no, thin, and thick pseudocapsules were 41% and 31%, respectively, 71% and 64%, respectively, and 88% and 88%, respectively; P < 0.001). In a multivariate analysis using the Cox proportional hazards model, after adjusting for other potential prognostic factors (vascular invasion, bile ductal invasion, number of tumors, tumor size, and curativeness of surgery), the presence of a fibrous pseudocapsule was an independent predictor of a favorable outcome after hepatic resection. CONCLUSIONS. The presence of fibrous tissue between the tumor and the liver parenchyma was a promising indicator of a better prognosis after resection in patients with colorectal liver metastases. (C) 2000 American Cancer Society.

KW - Colorectal carcinoma

KW - Fibrous pseudocapsule

KW - Hepatic resection

KW - Liver metastases

KW - Prognosis

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