First successful perinatal management of pregnancy after ABO-incompatible liver transplantation

Hisanobu Higashi, Hideaki Obara, Kei Miyakoshi, Masahiro Shinoda, Minoru Kitago, Naoki Shimojima, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Kentaro Matsubara, Yohei Yamada, Osamu Itano, Ken Hoshino, Tatsuo Kuroda, Yuukou Kitagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABO-incompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge. She was discharged uneventfully on postoperative day 38 without any rejection episodes. At 1 year and 6 mo after transplantation, she indicated a wish to become pregnant. Therefore, treatment with mycophenolate mofetil was interrupted at that time. After two miscarriages, she finally became pregnant and delivered transvaginally 3 years after the transplantation. All of the pregnancies were conceived naturally. The newborn was female with a birth weight of 3146 g; the Apgar scores were 9 and 10. Delivery was performed smoothly, and the newborn exhibited no malformations. The mother and the newborn were discharged uneventfully. We suggest that pregnancy is possible for recipients after ABO-incompatible liver transplantation.

Original languageEnglish
Pages (from-to)547-550
Number of pages4
JournalWorld Journal of Gastroenterology
Volume23
Issue number3
DOIs
Publication statusPublished - 2017 Jan 21

Fingerprint

Liver Transplantation
Pregnancy
Newborn Infant
Transplantation
Mycophenolic Acid
Apgar Score
Acute Liver Failure
Methylprednisolone
Tacrolimus
Spontaneous Abortion
Spouses
Birth Weight
Immunosuppression
Hepatitis
Maintenance
Mothers
Therapeutics

Keywords

  • ABO-incompatible
  • Delivery
  • Fulminant hepatic failure
  • Liver transplantation
  • Living donor
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. / Higashi, Hisanobu; Obara, Hideaki; Miyakoshi, Kei; Shinoda, Masahiro; Kitago, Minoru; Shimojima, Naoki; Abe, Yuta; Hibi, Taizo; Yagi, Hiroshi; Matsubara, Kentaro; Yamada, Yohei; Itano, Osamu; Hoshino, Ken; Kuroda, Tatsuo; Kitagawa, Yuukou.

In: World Journal of Gastroenterology, Vol. 23, No. 3, 21.01.2017, p. 547-550.

Research output: Contribution to journalArticle

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