First total synthesis of potent antitumour agent (+)-goniopypyrone

Tony Kung Ming Shing, Tsui Hon-Chung, Zhou Zhao-Hui

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from d-glycero-d-gulo-heptono-γ-lactone with an overall yield of 9.7 %.

Original languageEnglish
Pages (from-to)691-692
Number of pages2
JournalTetrahedron Letters
Volume34
Issue number4
DOIs
Publication statusPublished - 1992 Jan 22
Externally publishedYes

Fingerprint

Mustelidae
Stereochemistry
Lactones
Antineoplastic Agents
goniopypyrone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

First total synthesis of potent antitumour agent (+)-goniopypyrone. / Shing, Tony Kung Ming; Hon-Chung, Tsui; Zhao-Hui, Zhou.

In: Tetrahedron Letters, Vol. 34, No. 4, 22.01.1992, p. 691-692.

Research output: Contribution to journalArticle

Shing, Tony Kung Ming ; Hon-Chung, Tsui ; Zhao-Hui, Zhou. / First total synthesis of potent antitumour agent (+)-goniopypyrone. In: Tetrahedron Letters. 1992 ; Vol. 34, No. 4. pp. 691-692.
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